Preincubation: denitrifier community enzyme induction
Potential mechanisms of interactions include liver enzyme induction
and displacement of AEDS from protein binding sites.
Whatever the reason, this study along with our previous work using isolated monocytes [18, 22, 23], provides no evidence to support the hypothesis that enzyme induction
is substantially different in young and elderly individuals.
(1997), which is also based on enzyme induction
, was significantly associated with TSH levels ([beta]= 0.11; 95% CI, 0.02 to 0.20).
This confirmed that Danshen has no enzyme induction
effect on rat CYP1A2, despite previous findings that Danshen extracts may exert an inducing effect of CYP1A2 in the mouse (Kuo et al., 2006) and oral treatment with tanshinone IIA (50, 75, or 100mg/kg/ day, 5 days) had inducing effect on CYP1A2 in C57BL/ 6J but not in DBA/2J mice (Ueng et at, 2004).
Biomarkers of hepatic enzyme induction
. Results for hepatic enzyme induction
biomarkers are presented in Table 2.
By using in vitro assays of CYP enzyme induction
or inhibition the properties of a large number of isolated pure compounds can be conveniently estimated.
Talalay P, Fahey JW, Holtzelaw WD, Prestera T, Zhang Y (1995) Chemoprevention against cancer by phase II enzyme induction
. Toxicol Lett 82-83: 173-179
Physiologically based pharmacokinetic models have demonstrated that 10-fold differences in enzyme levels may make little difference in bioactivation of a chemical, as the chemical is completely metabolized at low doses in the absence of enzyme induction
. The application of data to risk assessment will be aided by the development of models of gene expression of oncogenes and tumor suppressor genes and modeling of polymorphisms of susceptibility.
Because of its role in the degradation of amyloid beta peptides this enzyme induction
of NEP by long term treatment with green tea extract may have a beneficial effect regarding the prevention of forming amyloid plaques.
Human placental cytochrome P450 and quinone reductase enzyme induction
in relation to maternal smoking.
Dioxin-like effects include weight loss, thymic atrophy, enzyme induction
, immunotoxicity, teratogenicity, dermatologic effects, carcinogenicity, and endocrine disruption (4).