Protein binding and liver
enzyme induction properties of AEDS can influence the blood levels of other drugs as well as other AEDS.
1997), which is also based on
enzyme induction, was significantly associated with TSH levels ([beta]= 0.
This confirmed that Danshen has no
enzyme induction effect on rat CYP1A2, despite previous findings that Danshen extracts may exert an inducing effect of CYP1A2 in the mouse (Kuo et al.
The systemic exposure as measured by AUC and Cmax was proportional to the total dose given either once-a-day or twice-a-day and was similar between Day One and Day Seven of dosing indicating no evidence of accumulation,
enzyme induction or inhibition.
For ACE,
enzyme induction appears to be associated with mitogen-activated protein kinase and early growth response 1 transcription factor (Day et al.
We measured biomarkers indicative of liver
enzyme induction and investigated the relationship with organochlorine body burden in adult volunteers from this population.
Role of phase 2
enzyme induction in chemoprotection by dithiolethiones.
By using in vitro assays of CYP
enzyme induction or inhibition the properties of a large number of isolated pure compounds can be conveniently estimated.
MultiCell's progenitor cells and immortalized liver cells are used by XenoTech, Pfizer, Bristol Myers Squibb and a growing number of other pharmaceutical companies to improve the safety profile of drugs by identifying early in the drug development program those drug candidates that can cause clinically significant
enzyme induction and drug-drug interactions.
Physiologically based pharmacokinetic models have demonstrated that 10-fold differences in enzyme levels may make little difference in bioactivation of a chemical, as the chemical is completely metabolized at low doses in the absence of
enzyme induction.
Talalay P, Fahey JW, Holtzelaw WD, Prestera T, Zhang Y (1995) Chemoprevention against cancer by phase II
enzyme induction.
Because of its role in the degradation of amyloid beta peptides this
enzyme induction of NEP by long term treatment with green tea extract may have a beneficial effect regarding the prevention of forming amyloid plaques.
