Protein binding and liver enzyme induction
properties of AEDS can influence the blood levels of other drugs as well as other AEDS.
1997), which is also based on enzyme induction
, was significantly associated with TSH levels ([beta]= 0.
This confirmed that Danshen has no enzyme induction
effect on rat CYP1A2, despite previous findings that Danshen extracts may exert an inducing effect of CYP1A2 in the mouse (Kuo et al.
The systemic exposure as measured by AUC and Cmax was proportional to the total dose given either once-a-day or twice-a-day and was similar between Day One and Day Seven of dosing indicating no evidence of accumulation, enzyme induction
For ACE, enzyme induction
appears to be associated with mitogen-activated protein kinase and early growth response 1 transcription factor (Day et al.
We measured biomarkers indicative of liver enzyme induction
and investigated the relationship with organochlorine body burden in adult volunteers from this population.
Role of phase 2 enzyme induction
in chemoprotection by dithiolethiones.
By using in vitro assays of CYP enzyme induction
or inhibition the properties of a large number of isolated pure compounds can be conveniently estimated.
MultiCell's progenitor cells and immortalized liver cells are used by XenoTech, Pfizer, Bristol Myers Squibb and a growing number of other pharmaceutical companies to improve the safety profile of drugs by identifying early in the drug development program those drug candidates that can cause clinically significant enzyme induction
and drug-drug interactions.
Physiologically based pharmacokinetic models have demonstrated that 10-fold differences in enzyme levels may make little difference in bioactivation of a chemical, as the chemical is completely metabolized at low doses in the absence of enzyme induction
Talalay P, Fahey JW, Holtzelaw WD, Prestera T, Zhang Y (1995) Chemoprevention against cancer by phase II enzyme induction
Because of its role in the degradation of amyloid beta peptides this enzyme induction
of NEP by long term treatment with green tea extract may have a beneficial effect regarding the prevention of forming amyloid plaques.