enzyme induction


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enzyme induction

[′en‚zīm in′dək·shən]
(microbiology)
The process by which a microbial cell synthesizes an enzyme in response to the presence of a substrate or of a substance closely related to a substrate in the medium.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Potential mechanisms of interactions include liver enzyme induction and displacement of AEDS from protein binding sites.
Whatever the reason, this study along with our previous work using isolated monocytes [18, 22, 23], provides no evidence to support the hypothesis that enzyme induction is substantially different in young and elderly individuals.
(1997), which is also based on enzyme induction, was significantly associated with TSH levels ([beta]= 0.11; 95% CI, 0.02 to 0.20).
This confirmed that Danshen has no enzyme induction effect on rat CYP1A2, despite previous findings that Danshen extracts may exert an inducing effect of CYP1A2 in the mouse (Kuo et al., 2006) and oral treatment with tanshinone IIA (50, 75, or 100mg/kg/ day, 5 days) had inducing effect on CYP1A2 in C57BL/ 6J but not in DBA/2J mice (Ueng et at, 2004).
Biomarkers of hepatic enzyme induction. Results for hepatic enzyme induction biomarkers are presented in Table 2.
By using in vitro assays of CYP enzyme induction or inhibition the properties of a large number of isolated pure compounds can be conveniently estimated.
Talalay P, Fahey JW, Holtzelaw WD, Prestera T, Zhang Y (1995) Chemoprevention against cancer by phase II enzyme induction. Toxicol Lett 82-83: 173-179
Physiologically based pharmacokinetic models have demonstrated that 10-fold differences in enzyme levels may make little difference in bioactivation of a chemical, as the chemical is completely metabolized at low doses in the absence of enzyme induction. The application of data to risk assessment will be aided by the development of models of gene expression of oncogenes and tumor suppressor genes and modeling of polymorphisms of susceptibility.
Because of its role in the degradation of amyloid beta peptides this enzyme induction of NEP by long term treatment with green tea extract may have a beneficial effect regarding the prevention of forming amyloid plaques.
Human placental cytochrome P450 and quinone reductase enzyme induction in relation to maternal smoking.
Dioxin-like effects include weight loss, thymic atrophy, enzyme induction, immunotoxicity, teratogenicity, dermatologic effects, carcinogenicity, and endocrine disruption (4).