Enzyme Inhibitor

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Related to Enzyme Inhibitor: reversible inhibition, angiotensin converting enzyme inhibitor

The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Enzyme Inhibitor

a chemical substance that selectively inhibits the activity of an enzyme or a group of related enzymes. Even in very low concentrations, enzyme inhibitors repress an organism’s vital physiological functions. Many toxic substances, including pesticides, such nerve gases as lewisite, and such respiratory toxins as cyanides and hydrogen sulfide, have a toxic effect owing to the inhibition of enzymes, for example, the enzyme cholinesterase in arthropods.

The study of the effect of enzyme inhibitors on enzymes or groups of enzymes facilitates the search for antidotes or for new pesticides to control harmful insects, mites and ticks, and weeds. The term “enzyme inhibitors” sometimes refers to enzymes in the poisons of snakes, bees, and scorpions that destroy tissues or blood cells in man and animals.

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References in periodicals archive ?

Fiskio et al., "An evaluation of risk factors for adverse drug events associated with angiotensin-converting enzyme inhibitors," Journal of Evaluation in Clinical Practice, vol.

Assessment of 105 Patients with Angiotensin Converting Enzyme-Inhibitor Induced Angioedema

Zivljenje ogrozajoc angioedem po zaviralcu angiotenzinove konvertaze: prikaz dveh primerov [Life-threatening angioedema induced by angiotensin-converting enzyme inhibitor: two case reports].

Angiotensin-converting enzyme inhibitors as a cause of isolated angioedema in a Slovenian population

The development of angiotensin I-converting enzyme inhibitor derived from chicken bone protein.

Angiotensin I-converting enzyme inhibitor activity on egg albumen fermentation

The aim of this study was to elucidate the combined effect of the clinically used vitamin K(2) (VK) and angiotensin-converting enzyme inhibitor (ACE-I) on cumulative recurrence after curative treatment on a total of 87 patients, especially in consideration of neovascularization.METHODS: VK (menatetrenone; 45 mg/day) and/or ACE-I (perindopril; 4 mg/day) were administered for 36-48 months after curative therapy for HCC.

Journal abstracts: combination of vitamin K2 and angiotensin-converting enzyme inhibitor ameliorates cumulative recurrence of hepatocellular carcinoma

A potential immunotherapy, a new gene therapy, an enzyme inhibitor, and a compound originally isolated from a Chinese herb are among the latest approaches scientists are proposing to treat addiction.

First NIDA Avant-Garde Awards for Medications Development Research

Lead researcher Dr Gerd Wagner, from the University of East Anglia, said: "This exciting discovery of a potent enzyme inhibitor with a completely new mechanism of action has considerable therapeutic potential in cancer, inflammation and infection.

A NEW family of molecules [...]

The actual ingredients are an angiotensin-converting enzyme inhibitor (ramipril 5 mg), a beta-blocker (atenolol 50 mg), a diuretic (hydrochlorothiazide 12.5 mg), the statin simvastatin 20 mg, and aspirin 100 mg.

The polypill

Angiotensin-converting enzyme inhibitor induced syndrome of inappropriate secretion of antidiuretic hormone: case report and review of the literature.

Acute severe hyponatraemia and seizures associated with postoperative enalapril administration

Hsu, Bates, Kuperman & Curhan (2001), in their study, "Blood pressure and angiotensin converting enzyme inhibitor use in hypertensive patients with chronic renal insufficiency," sought to investigate actual clinical management of hypertension in 3,089 ambulatory patients with CKD by using medical record information from a Massachusetts hospital.

The use of ACE inhibitors and ARBs in severe chronic kidney disease: point--counterpoint

Coreg is an excellent drug for this problem, and often an angiotensin-converting enzyme inhibitor or receptor blocker is added.

Advances in heart care

Shades of colour can be correlated to the amount of substrate or enzyme inhibitor present.

The Chemistry of the test process

The covalently bound entity may also serve as an antagonist or agonist of a particular binding protein or as an enzyme inhibitor. (US 7,166,695)