Eosinophil


Also found in: Dictionary, Thesaurus, Medical, Acronyms, Wikipedia.
Related to Eosinophil: basophil, monocyte

eosinophil

[‚ē·ə′sin·ə‚fil]
(histology)
A granular leukocyte having cytoplasmic granules that stain with acid dyes and a nucleus with two lobes connected by a thin thread of chromatin.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Eosinophil

 

a cell of vertebrates, including man, whose cytoplasm contains rounded granular structures that are stained by acid dyes, in particular by eosin. The eosinophils of the blood originate and mature in the bone marrow. They comprise 3–4 percent of leukocytes in the peripheral blood of a healthy human being. This level is subject to a daily rhythm and is regulated by the system which includes the pituitary body and the adrenal cortex.

In allergic reactions, eosinophils release the inhibitor histamine, which belongs to the prostaglandins E1 and E2. They also serve as phagocytes.

An increase in the percentage of eosinophils in the peripheral blood or an increase in their absolute number is called eosinophilia. As a rule, this condition is reactive in character, regardless of the degree of its severity. The possibility of developing eosinophilic leukemia is still a matter of dispute. Eosinophilia is accompanied by various reactions and diseases, predominantly allergic, including those related to the breaking down of the body’s resistance by parasites or medicinal and food allergens. Aggregations of eosinophils observed in the tissues, as, for example, in the mucosa of the bronchi (and sputum) in bronchial asthma, are called tissue eosinophilia. Eosinophilic infiltrates, large aggregations of eosinophils in the tissues, are occasionally observed in various organs, predominantly the lungs. They may run their course as short-term reactions or result in such severe illnesses as pneumonia, myocarditis, vasculitis, and meningoencephalitis. A number of other diseases are also accompanied by a high eosinophilia. In some cases it is impossible to establish the nature of the disease that is accompanied by a high eosinophilia. The condition may be observed even in people who are otherwise healthy.

Hürtle cells, one of the types of cells of the anterior lobe of the pituitary body, are also called eosinophils.

L. D. GRINSHPUN

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
When a person has symptoms and an elevated number of eosinophils in their tissues, organs, and/or bloodstream, without a known cause, he/she may have an eosinophil-associated disease.
(18) found that serum ECP was higher in AR patients and correlated with the blood eosinophil count in AR patients.
There are contradictory results in previous studies analyzing the correlation of ECP with AEC and esophageal tissue eosinophil count.
(1) No research has been done to evaluate the prevalence of dominant inflammatory cells in people with fungal rhinosinusitis, especially in Indonesia, but allergic fungal rhinosinusitis as the most common form of fungal rhinosinusitis has a dominance of eosinophil cells.
On the other hand, there are some inspiring discoveries, such as dupilumab and tezepelumab seem to have good effects on patients with both high and low eosinophil numbers; our group found Bcl-2 inhibitors can reduce the inflammation in the airway.
Despite the acknowledged contribution of eosinophils to the disease pathogenesis, available data on cytokines closely related to the development and activity of peripheral eosinophils in IBD patients are either scattered or nonexistent.
Ours is the first to systematically compare 10 additional histological criteria, apart from the eosinophil count, in EoED and EoE-AP at diagnosis.
We believed that reduction of eosinophil accumulation in the airways of diabetic mice, after antigen stimulation, could importantly contribute to the lower AHR, as it has been demonstrated a causal relationship between eosinophilic airway inflammation and AHR [51].
The innate immune system components include granulocytes or polymorph nuclear leukocytes, the group to which neutrophils, eosinophils and basophils, macrophages/monocytes, and natural killer cells (NK cells).
She presented with an eosinophil count of over 400 cells/microL.
IL-5 is a pivotal eosinophil hematopoietin with pleiotropic effects on the development, recruitment, differentiation, maturation, migration, activation, and survival of eosinophils (4, 12).

Full browser ?