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A granular leukocyte having cytoplasmic granules that stain with acid dyes and a nucleus with two lobes connected by a thin thread of chromatin.



a cell of vertebrates, including man, whose cytoplasm contains rounded granular structures that are stained by acid dyes, in particular by eosin. The eosinophils of the blood originate and mature in the bone marrow. They comprise 3–4 percent of leukocytes in the peripheral blood of a healthy human being. This level is subject to a daily rhythm and is regulated by the system which includes the pituitary body and the adrenal cortex.

In allergic reactions, eosinophils release the inhibitor histamine, which belongs to the prostaglandins E1 and E2. They also serve as phagocytes.

An increase in the percentage of eosinophils in the peripheral blood or an increase in their absolute number is called eosinophilia. As a rule, this condition is reactive in character, regardless of the degree of its severity. The possibility of developing eosinophilic leukemia is still a matter of dispute. Eosinophilia is accompanied by various reactions and diseases, predominantly allergic, including those related to the breaking down of the body’s resistance by parasites or medicinal and food allergens. Aggregations of eosinophils observed in the tissues, as, for example, in the mucosa of the bronchi (and sputum) in bronchial asthma, are called tissue eosinophilia. Eosinophilic infiltrates, large aggregations of eosinophils in the tissues, are occasionally observed in various organs, predominantly the lungs. They may run their course as short-term reactions or result in such severe illnesses as pneumonia, myocarditis, vasculitis, and meningoencephalitis. A number of other diseases are also accompanied by a high eosinophilia. In some cases it is impossible to establish the nature of the disease that is accompanied by a high eosinophilia. The condition may be observed even in people who are otherwise healthy.

Hürtle cells, one of the types of cells of the anterior lobe of the pituitary body, are also called eosinophils.


References in periodicals archive ?
Degenerated epithelial cells with eosinophilic globular material resembling viral inclusions were observed in tissue collected from the tongue, suggesting that this macaw also had the diphtheritic form of avian pox.
Eosinophilic oesophagitis in Cape Town, South Africa (abstract).
Microscopically, the tumor was composed of nests to sheets of polygonal cells with eosinophilic granular cytoplasm and very sharp, distinct cell borders.
Key clinical point: Topical steroids seemed to improve mucosal integrity in patients with eosinophilic esophagitis, but proton pump inhibitor therapy did not.
1] It has an unknown etiology, though it is characterized by numerous eosinophilic infiltrations of the bladder.
The American Partnership for Eosinophilic Disorders (APFED) will celebrate the 7th annual National Eosinophil Awareness Week May 18- May 24 by uniting patients, families, patient advocacy groups, medical institutions, medical societies, physicians, and companies that support those who have eosinophil-associated diseases in effort to create awareness and educate the public and the medical community about these diseases.
2008), and eosinophilic or basophilic granulocytes (Friebel & Renwrantz 1995, Aladaileh et al.
67) Consistent with its role in the development of eosinophilic leukemia, the activated fusion protein is capable of promoting eosinophil-lineage commitment in hematopoietic progenitor cells in vitro.
Eosinophilic esophagitis: rapidly emerging disorder.
3] (with differential count as P-30, L-20, E-40, M-01) and absolute eosinophilic count-5800 cells/[mm.
Histological examination and biopsies from the gastric antrum and duodenum demonstrated subacute and chronic inflammation with distinct eosinophilic infiltration of the submucosa and muscularis.
Eosinophilic ulcer of the oral mucosa: Another histological simulator of CD30+ lymphoproliferative disorders.

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