granulomatosis

(redirected from eosinophilic granulomatosis)
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Related to eosinophilic granulomatosis: Langerhans cell granulomatosis

granulomatosis

[‚gran·yə‚lō·mə′tō·səs]
(medicine)
Any disease characterized by multiple granulomas.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Respiratory medicine company GlaxoSmithKline plc (LSE:GSK)(NYSE:GSK) reported on Tuesday the receipt of approval from the US Food and Drug Administration (FDA) for Nucala (mepolizumab) for the first targeted treatment for eosinophilic granulomatosis with polyangiitis (EGPA), previously known as Churg-Strauss syndrome.
Of these, eosinophilic granulomatosis with polyangiitis, formerly known as Churg-Strauss syndrome, is associated with severe eosinophilia.
Sokolowska et al., "Noncorticosteroid immunosuppression limits myocardial damage and contractile dysfunction in eosinophilic granulomatosis with polyangiitis (churg-strauss syndrome)," Journal of the American College of Cardiology, vol.
"This study demonstrates that skin lesions are quite common and varied in granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis," the investigators concluded.
It is part of a larger group of antineutrophil cytoplasmic antibody (ANCA) associated autoimmune vasculitic syndromes including Eosinophilic Granulomatosis with Polyangiitis (EGPA), polyarteritis nodosa, and microscopic polyangiitis [2].
The autoimmune/idiopathic disorders most commonly associated with eosinophilia are eosinophilic granulomatosis with polyangiitis (EGPA, also known as Churg-Strauss syndrome), Kimura disease, immunoglobulin (Ig)G4-related disease, diffuse fasciitis with eosinophilia, and eosinophilic myositis.
THE FOOD AND DRUG Administration approved mepolizumab to treat adult patients with eosinophilic granulomatosis with polyangiitis (EGPA) in December, making it the first therapy approved for treating this rare disease.
AAV comprises three different diseases: granulomatosis with polyangiitis (GPA), eosinophilic granulomatosis with polyangiitis, and microscopic polyangiitis [2].
The most common reason of pauci-immune GNs is anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, including granulomatosis with polyangiitis, microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis, and renal limited vasculitis (1).
Eosinophilic granulomatosis (EG) can incidentally be found with malignancy and has been found to coexist with lymphoma.
Subsets include eosinophilic gastrointestinal disorders (affects esophagus, stomach, or intestines); eosinophilic granulomatosis with polyangiitis, aka Churg-Strauss Syndrome, (affects lungs, sinuses, heart, and various organ systems); and hypereosinophilic syndrome (affects blood and organs).

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