ephedrine


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ephedrine

(ĭfĕd`rĭn, ĕf`ĭdrēn'), drug derived from plants of the genus Ephedra (see PinophytaPinophyta
, division of the plant kingdom consisting of those organisms commonly called gymnosperms. The gymnosperms, a group that includes the pine, have stems, roots and leaves, and vascular, or conducting, tissue (xylem and phloem).
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), most commonly used to prevent mild or moderate attacks of bronchial asthma. Unlike epinephrineepinephrine
, hormone important to the body's metabolism, also known as adrenaline. Epinephrine, a catecholamine, together with norepinephrine, is secreted principally by the medulla of the adrenal gland.
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, to which it is chemically similar, ephedrine is slow to take effect and of mild potency and long duration. A bronchodilator and decongestant, ephedrine is used to relieve nasal congestion originating from allergic conditions, e.g., hay fever, or from bacterial or viral infection of the upper respiratory tract. It may be used as well to raise blood pressure. Ephedrine also is used in the production of methamphetamine (see amphetamineamphetamine
, any one of a group of drugs that are powerful central nervous system stimulants. Amphetamines have stimulating effects opposite to the effects of depressants such as alcohol, narcotics, and barbiturates.
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).

Ephedrine is the active constituent of ma huang, an herbal preparation used medically in China for thousands of years. Also commonly known as ephedra, it is derived from several Asian species of Ephedra. Preparations of these species were formerly used in "natural" dieting aids and bodybuilding supplements and also were marketed as "herbal ecstasyecstasy,
either of two drugs used for their euphoric effects. The original ecstasy, a so-called designer drug, also known as MDMA, is an analog of methamphetamine (see amphetamine).
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." Ephedra and ma huang may cause such side effects as insomnia, restlessness, euphoria, palpitations, and high blood pressure; there have been reports of a number of deaths associated with their use as recreational drugs and dietary supplements. In 2004 the Food and Drug Administration banned sales of dietary supplements containing ephedra because of illnesses and deaths associated with the drug.

Ephedrine

 

C6H5CH(OH)CH(NHCH3)CH3, an alkaloid contained in various species of plants of the genus Ephedra. Ephedrine was first isolated in 1887. Its effect is similar to that of adrenaline; it excites the central nervous system. Ephedrine hydrochloride is used in the treatment of, for example, bronchial asthma, hypotension, allergic diseases, blood loss, and overdoses of narcotics and somnifacients.

ephedrine

[ə′fed·rən]
(organic chemistry)
C10H15NO A white, crystalline, water-soluble alkaloid present in several Ephedra species and also produced synthetically; a sympathomimetic amine, it is used for its action on the bronchi, blood pressure, blood vessels, and central nervous system.

ephedrine

, ephedrin
a white crystalline alkaloid obtained from plants of the genus Ephedra: used for the treatment of asthma and hay fever; l-phenyl-2-methylaminopropanol. Formula: C6H5CH(OH)CH(NHCH3)CH3
References in periodicals archive ?
It is said the infamous, even if yet to be concluded, ephedrine case being heard in the country for the last five years or so has awakened the Pakistani government to the challenges of preventing illegal ephedrine drugs.
The syringe in group 1 (study group, n=45) contained ephedrine 10 mg plus phenylephrine 125 mcg that had reached 15 mL with normal saline serum (NaCl 0.
On Thursday, accused involved in Ephedrine case including owner of Grace Pharma Hanif Abbasi, Basit Abbasi, Siraj Abbasi, Marketing Manager Rana Mohsin Khurshid, Production Manager Ghazanfar Ali, Quality Control Manager Nasir Khan and owner of AB Pharmaceutical Ahmed Bilal were present in the court while counsel for Hanif Abbasi, Tanvir Iqbal Advocate and ANF lawyer Chaudhry Zahid Mehmood and ANF case special law inspector Mirza Abdul Rehman were also present.
The company said the Ephedrine sulfate injection is indicated for the treatment of clinically important hypotension occurring in the setting of anesthesia.
Conclusion: It is concluded from the results of this study that less preloading is required in intramuscular ephedrine group and hence preloading along with intramuscular ephedrine is more effective in preventing hypotension in elderly patients after spinal anaesthesia as compared to preloading alone.
Jacquelyn de Guzman, in collaboration with a team from PAOCC, after he sold powdered ephedrine to a poseur-buyer along Rizal Avenue corner Bambang Street, Manila.
Chief Inspector Roque Merdegia, a spokesperson for the anti-illegal drugs special operations task force (AIDSOTF), in a text message to media, said they were surprised when the laboratory tests showed that the 10 sacks seized in Barangay (village) Don Galo in Paranaque contained ephedrine and not shabu (methamphetamine hydrochloride).
Pseudoephedrine and ephedrine are precursor drugs used to manufacture amphetamine-type substances, including methamphetamine ( ice ).
Therefore, products containing ephedrine are not to be used by people with heart disease, hypertension, diabetes, thyroid disease, enlarged prostate, anxiety, glaucoma, under monoamine oxidase inhibitors treatment or women who are pregnant or lactating (Wooltorton et al.
A fresh charge sheet submitted by the Anti-Narcotics Force said that Gilani himself had approved a quota of 1,000-kilogrammmes of ephedrine for Dr Javed Siddiqi, a former member of the National Assembly.