epidermal growth factor


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epidermal growth factor

[‚ep·ə¦dərm·əl ′grōth ‚fak·tər]
(physiology)
A polypeptide produced in animals that stimulates and sustains the replication of epidermal cells (of ectodermal or endodermal origin); its human equivalent is urogastrone.
References in periodicals archive ?
Epidermal growth factor (EGF) system has been strongly related to the regulation of the cyclical growth and shedding of human endometrium (2).
The epidermal growth factor variant III peptide vaccine for treatment of malignant gliomas.
Direct positive effect of epidermal growth factor on the cytoplasmic maturation of mouse and human oocytes.
The epidermal growth factor receptor: from mutant oncogene in nonhuman cancers to therapeutic target in human neoplasia.
Alan Venook, M.D., professor of clinical medicine and chief of the section on gastrointestinal oncology, University of California, San Francisco, said the results may validate epidermal growth factor as a target for pancreatic cancer and "certainly gives us clues for subsequent studies that might capitalize on this" mechanism for new treatments.
Cetuximab is a monoclonal antibody directed against the epidermal growth factor receptor.
Topical synthetic epidermal growth factor serum moderately improved the appearance of atrophic acne scars in a small pilot study.
Major role in growth and differentiation for a variety of malignant and normal cells retinoids are regarded to have an important function.They are known to play a major role in regulatinggrowth and differentiation of a variety of normal and malignant cells.11Topical all trans RA treatment caused an increase in the number of living cell layers in the epidermis of both human and mouse.1213It has been reported that retinoic acid treatmentresults in expression of post-transcriptional elevation in epidermal growth factor receptors (EGF R).14The epidermal growth factor receptor (EGFR) is the cell surface receptor for members of the epidermal growth factor family (EGF family) of extracellular protein ligands.
The researchers began by studying four different types of breast cancer cells that were able to keep growing despite treatment with lapatinib, a powerful drug that targets two growth pathways commonly disrupted in breast cancer, HER2 and epidermal growth factor receptor.
Curcumin exhibits activities similar to recently discovered tumor necrosis factor blockers (e.g, HUMIRA, REMICADE, and ENBREL), a vascular endothelial cell growth factor blocker (e.g., AVASTIN), human epidermal growth factor receptor blockers (e.g., ERBITUX, ERLOTINIB, and GEFTINIB), and a HER2 blocker (e.g., HERCEPTIN).
The proposed use of Tarceva is for first-line monotherapy in people diagnosed with advanced EGFR (epidermal growth factor receptor) activating mutation positive NSCLC.

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