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Hypertrophy of the cornea.
Hypertrophy of the horny layer of the skin.



excessive development of the corneous layer of the skin in humans. Hyperkeratosis may be caused by external factors (such as prolonged pressure, friction, or the effects of lubricating oils) or internal factors (endocrine dysfunctions, hypovitaminosis A, occupational intoxication). Hyperkeratosis is manifested by the formation of horny plates, nodes of various sizes, protuberances, and spurs; the skin becomes dry and perspiration decreases. Hyperkeratosis may be accompanied by the formation of painful cracks (on the palms and soles). It may be limited (calluses, warts, keratomas) or diffuse, spread over large areas or the entire skin surface (ichthyosis). Treatment consists in soda or soap baths, vitamin therapy, and medications that dissolve the horny substance.

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B, Higher magnification reveals features of epidermolytic hyperkeratosis: cytoplasmic vacuolation, coarse keratohyalin granules, and perinuclear eosinophilic inclusions in the spinous and granular layers (hematoxylin-eosin, original magnifications X40 [A] and X400 [B]).
It was later described by various names by other authors like nevus verrucous, systematized epidermal nevus and epidermolytic hyperkeratosis.Gianotti,6 in 1980, classified it as a localized form of congenital epidermolytic hyperkeratosis.
It is also known as epidermolytic hyperkeratosis.1 BIE is transmitted as an autosomal dominant trait with a prevalence of approximately 1 in 200000 to 300000 persons.

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