epigenetic


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Related to epigenetic: Epigenetic Theory

epigenetic

[¦ep·ə·jə¦ned·ik]
(geology)
Produced or formed at or near the surface of the earth.
References in periodicals archive ?
With the growing recognition of the importance of epigenetic signalling, potent and selective small molecules targeting the WDR5/MLL1 interface present a potential therapeutic intervention in leukemias and some p53/myc-driven cancers.
The grandchildren's health was likely influenced by their ancestors' gametes (sperm or egg), which carried specific epigenetic marks -- e.
Epigenetic marks have been shown in rodents to influence behaviors such as maternal care and drug addiction (SN: 5/24/08, p.
2) Epigenetic control of DNA expression strengthens specific synaptic connections over others and is the specific mechanism whereby experience and environment can exert physical changes within the brain.
We are very pleased that Beactica's epigenetic project was selected for this highly competitive grant.
Further research is needed to explain the association between metal exposure, these epigenetic marks, and various health effects," says Rebecca Fry, a molecular toxicologist at the University of North Carolina School of Public Health.
The results showed that genetic differences alone best explained 25 per cent of the epigenetic variation between babies, with the remaining 75 per cent best explained by the interaction of genetic differences and the prenatal environment.
These findings give some hope that if we are able to reverse or bring about compensatory epigenetic changes, we might be on the right path to developing successful antidepressant therapies.
If scientists could identify epigenetic marks in people, then change them with diet or drugs, they could, at least in theory, silence cancer, obesity, or diabetes.
One crucial epigenetic mechanism involves methylation of the DNA, particularly in regulatory regions, which typically results in the silencing of genes.
DNA methylation is the most extensively studied epigenetic modification in humans.
Azim Surani, who was not involved in this study, said "This elegant study on TRIM28 provides significant mechanisticinsights on how maternal factors in eggs ensure faithful epigenetic inheritance that plays a critical role during development.