epimer


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epimer

[′ep·ə·mər]
(organic chemistry)
A type of isomer in which the difference between the two compounds is the relative position of the H (hydrogen) group and OH (hydroxyl) group on the last asymmetric C (carbon) atom of the chain, as in the sugarsD-glucose andD-mannose.
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For instance, our group has shown that the treatment of diabetic mice with D-chiro-inositol, an epimer of myo-inositol, can restore nerve conduction velocity and preserve nerve structural integrity (24) and that D-chiroinositol, methyl-D-chiro-inositol, and dibutyryl-D-chiro-inositol can prevent and ameliorate somatic and autonomic nerve function in rats and rabbits (37).
Although both 3-FCA epimers are a substrate for the bile acid transporters, 3[alpha]-FCA displays a slightly higher affinity than 3[beta]-FCA for NTCP and OATP1B1 (2.53 [+ or -] 0.76 [micro]M and 5.22 [+ or -] 0.56 [micro]M, resp., versus 6.18 [+ or -] 0.59 and 9.67 [+ or -] 0.83 [micro]M, resp.).
Petasis, Resolvin D1 and its aspirin-triggered 17R epimer. Stereochemical assignments, antiinflammatory properties, and enzymatic inactivation.
Galactose is a C-4 epimer of glucose and is catalyzed to glucose-1-phosphate by galactokinase, the rate-limiting step of metabolism for galactose exclusively in the liver [5, 6].
This represents a drastic decrease in estrogenicity from the 17[beta]-AED epimer. The presence of the hydroxyl group at C7 of 17[beta]-AET resulted in 1/587th the ability to activate the ER[beta].
The program recently began quantitating DEQAS materials with real values assigned by NIST, and is also working on standardizing measurements for 25(OH)D2 and D3, the C-3 epimer of 25(OH)D2 and D3, and 24,25(OH)2D, he said.
Among the estrogen-imprinted MIPs, 17[beta]-estradiol (E2) has been templated to develop MIPs as synthetic estrogen receptors (8-11).17[alpha]-Estradiol (a natural epimer of E2) (12) and 6-ketoecradiol (a pseudo E2) (13) were also reported for MIPs preparation to target E2.
Istanbul Universitesi Istanbul Tip Fakultesi, Noroloji Anabilim Dali ve Epilepsi Merkezi (Epimer), Istanbul, Turkiye
[4-8] The alginate chemical structure is composed of a polymer arranged in homopolymeric block structure of urinic acid [beta]-D-mannuronate and its C-5 epimer [alpha]-L-guluronate.
Cooccurrence of 9-isocyanopupukeanane and its C-9 epimer in the nudibranch Phyllidia bourguini.
However, the alkaloids ergosine, ergonine, ergine, and their epimers were detected in low amounts, while ergovaline and its epimer ergovalinine were the major components (about 80% of total) of the ergopeptine fraction, in agreement with Siegel and Bush (1997).
It is the epimer of arbutin, which even in very low concentration can inhibit the activity of tyrosinase.