epimerization


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Related to epimerization: racemization, Mutarotation

epimerization

[‚e·pim·ə·rə′zā·shən]
(organic chemistry)
In an optically active compound that contains two or more asymmetric centers, a process in which only one of these centers is altered by some reaction to form an epimer.
References in periodicals archive ?
Epimerization is the most common bioconversion found in the tissues of bivalves; the [beta]-epimers (C2, C4, GTX3, and GTX4) primarily produced by dinoflagellates are usually transformed to the more thermodynamically stable [alpha]-epimers (C1, C3, GTX2, and GTX1) after uptake by shellfish (Oshima 1995, Bricelj & Shumway 1998).
Epirubicin differs from adriamycin by the epimerization of the OH group in position 4' of the aminosugar moiety and has been shown to be less toxic during chemotherapeutic treatments against metastatic breast cancers (Ganzina 1983; reviewed by Hortabagyi 2000).
The epimerization strongly decreases the compound's biologic efficacy; the anabolic potency of TbOH-17[alpha] is only about 5% of that of TbOH-17[beta] (9), and the affinity to the recombinant human androgen receptor (rhAR) is reduced to about 4% (10).
Earliest modern humans in southern Africa dated by isoleucine epimerization in ostrich eggshell, Quaternary Science Reviews 18: 1537-48.