The first group arises as a result of developmental failure of a segment of the mesoderm and comprises three of the defects, which include diaphragmatic defect (which results from total or partial failure of the transverse septum to develop), pericardial defect (which is closely related to faulty development of the transverse septum), and intracardiac lesions (which is the result of faulty development of the epimyocardium
, which is derived from the splanchnic mesoderm) [8, 22, 24].
Let [C.sub.L] (t) indicate left epimyocardium
standard action potential of human and let [C.sub.R](t) indicate right epimyocardium
standard action potential of human.
At 1.2 cm CVRLbuffalo foetus, the heart tube was comprised of two layers namely; endocardium and epimyocardium
The diaphragmatic and pericardial defects are closely related to either the total or partial failure of septum transversum development, whereas the cardiac abnormalities result from the faulty development of the epimyocardium
. The sternal and abdominal wall defects represent faulty migration of these mesodermal primordial structures.