Epistasis

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Related to epistatic: dominant epistasis, modifier genes

epistasis

[ə′pis·tə·səs]
(genetics)
The suppression of the effect of one gene by another.
(medicine)
A checking or stoppage of a hemorrhage or other discharge.
(pathology)
A scum or film of substance floating on the surface of urine.

Epistasis

 

the interaction of two nonallelic genes (that is, genes that are at different loci) whereby one of them, called the epistatic gene, suppresses the effect of the other one, called the hypostatic gene. Phenotypically, epistasis is manifested as a deviation from the segregation that would be expected in digenetic inheritance; in this case, however, there is no violation of Mendel’s laws, inasmuch as the alleles of the interacting genes are distributed in complete conformity to the law of independent assortment, or combination.

References in periodicals archive ?
In our recent study [24], there was an epistatic interaction between CASR rs7652589 and rs1024611 in the chemokine (C-C motif) ligand 2 gene (CCL2) in nephrolithiasis-related ESRD.
Type 3 is more complex, and results from the disruption of favorable multilocus epistatic combinations through recombination with exogenous genomes.
the V-opioid receptor [MOPr]) in mice, epistatic interactions may be sexually dimorphic.
However, both of the QTLs were involved in significant epistatic interactions with QTL-M (Table 2).
Epistatic interactions can either reinforce or inhibit inbreeding depression, resulting in a nonlinear relationship between the trait value and inbreeding level (Crow and Kimura 1970).
This is because most of the genetic variance expressed by structural genes is additive and because genes with epistatic effects influence the response to individual selection through their contribution to the additive genetic variance (Crow and Kimura 1970).
By observing a significant kh2 value, a six parameter model was used to accommodate the digenic epistatic interactions.
The main effects, epistatic effects and environmental interactions of QTLs on the cooking and eating quality of rice in a doubled haploid line population.
The observation of a discrete distribution, the variable number of genes and the epistatic interactions of oligogenic traits motivate the search for and application of efficacious methods for analyzing oligogenic trait loci (OTL) (ROCHA et al.
The classical epistatic model included all the possible genetic interaction effects among multiple loci.
Certain gene or genes with dominant or epistatic effects are involved in the control of gray leaf spot resistance.