It is being proposed that a risk score comprising the most significantly associated variants for each blood pressure phenotype may be developed and evaluated for epistatic
effect amounts to several millimeters mercury of blood pressure (13).
At the same time, genetic and allelic heterogeneity, in the presence of unilocus mutational and phenotypic diversity, is making things complicated while it is providing clues for implicating epistatic
effects and modifier gene function in interpreting the complex picture we are faced with.
The authors suggested that the changes in intermediate ratios through the pathway might be the foundation for observed statistical epistatic
In addition, sexual polyploidization produces a wide array of complex epistatic
Five female families which included ma, black and white were also discarded because the recessive white gene, when homozygous, is epistatic
over all other color loci.
This strong relationship between the genotypes performance indicated that the mechanisms that control AE and UtE for N and P may be pleiotropic or epistatic
roles of E2 glycoprotein mutations in adaption of chikungunya virus to Aedes albopictus and Ae.
genetic variance is also produced by interactions among alleles but at different loci rather than at the same locus.
meningitidis and stresses the importance of epistatic
genetic interactions in disease susceptibility.
A major limitation of using a multiplicative interaction model to derive polygenic risk from single-gene studies is that epistatic
relationships are not considered.
effect of C-reactive protein (CRP) single nucleotide polymorphism (SNP) +1059 and interleukin 1B SNP +3954 on CRP concentration in healthy male blood donors.
Through the development of a novel experimental approach we shall elucidate complex epistatic
interaction networks between mutations accumulated during resistance evolution.