(5.) Tsoitis G, Mandineos C, Kanitakis JC: Perforating calcifying epithelioma
of Malherbe with a rapid evolution.
Demonstration of calcification, which is normally a feature of pilomatricoma (hence its other name of calcifying epithelioma
of Malherbe), is variable on MRI.
Sebaceous carcinomas have significantly increased nuclear staining with p53 and Ki-67 (MIB-1) and reduced levels of BCL2 and p21, in comparison to sebaceous adenomas and sebaceous epitheliomas
. The p53 protein is a tumor suppressor.
Since then, this uncommon entity has been called calcifying epithelioma
of Malherbe (2).It was believed to be a rare tumor, but increasing reports in the literature show that it is not uncommon.
This lesion was first described in 1880 by Malherbe and Chenantais who thought it to arise from sebaceous glands and called it calcifying epitheliomas
Broders, considering this information to be critical for patient care, then "transferred the grading system to the old pathologic reports in Mayo's files...and graded lesions forward to the point in the 1920s at which the grading of various squamous-cell epitheliomas
had become routine." (2)
Multiple familial trichoepithelioma (MFT) is also called as epithelioma
adenoids cysticum and Brooke-Fordyce trichoepitheliomas.1
Muir-Torre syndrome-associated sebaceous gland neoplasms include sebaceous adenoma, sebaceoma/sebaceous epithelioma
, sebaceous carcinoma, keratoacanthoma with sebaceous differentiation, and basal cell carcinoma (BCC) with sebaceous differentiation.
Familial multiple eccrine spiradenomas with cylindromatous features associated with epithelioma
adenoides cysticum of Brooke.
Case report of an unusual tumor of the vulva: epithelioma
of rearranged stroma or so-called mixed tumor [in French].