8226; Quantitative and qualitative - Epitope
description includes Positional Weight Matrix of amino acid residues in the peptide epitope
mapping, we used the peptide library of 18-mer overlapping peptides that covered the entire cTnI sequence.
is recognized by an antibody called 2F5, which can neutralize several strains of the virus.
A secondary objective of the study was to assess the immunogenicity of the vaccine as measured by the magnitude and epitope
breadth of the patients' cellular immune responses.
Complexity of the single linear neutralization epitope
of the mouse arterivirus lactate dehydrogenase-elevating virus.
These results demonstrate that protein structure plays an important role in the stability of this allergen to resist digestion and provide a link between food allergen structure, stability to digestion, and the immunodominant IgE-binding epitopes
within a population of food-allergic individuals.
A useful approach may involve the use of an expression library, whereby the genome of a pathogen is fragmented and the pieces of DNA captured to create a pathogen library that represents most of the T cell epitopes
that exist for that pathogen.
Ninety-one percent of patients treated with EP-2101, who were tested for immune response, had a measurable response to at least one of the epitopes
included in the vaccine with 64% responding to at least three of the epitopes
125]-labeled) that recognizes an epitope
different from those recognized by the other four is used as a tracer.
PADRE(R), the Company's proprietary universal HTL epitope
, is also included in the vaccine as an immunostimulant.
Epimmune is focused on the development of pharmaceutical products using multiple epitopes
to specifically activate the body's immune system.
However, the fact that MAbs recognize only a single epitope
means that they have limited usefulness against pathogens that exhibit antigenic variation.