The title of her presentation was "Vaccination with DerG LEAPS peptide conjugates incorporating distinct PG (aggrecan) epitopes
protects by different immune mechanisms in the PG G1 domain induced mouse model of rheumatoid arthritis."
Diagnostic performance and T-cell epitopes
may be different in cattle compared to humans; it is therefore necessary to identify and verify these promising T-cell epitopes
Combining the results of four programs, six antigenic epitope
peptides (amino acid positions 34-45, 63-67, 103-108, 224-230, 308-316, and 365-377) were predicted (Table 3, Figures 1 and 2).
The sequence corresponding to the B-cell epitope
of VP1 from FMDV O1/Campos/Bra/58 (140158) comprises the amino acid residues AVPNVRGDLQVLAQKVART.
The linear B-cell epitopes
in the primary amino acid sequence of the coat protein was performed using BCPREDS server with default parameters (http://ailab.cs.iastate.edu/ bcpreds/) which implements a support vector machine (SVM) and the subsequence kernel method (El-Manzalawy et al., 2008a).
Masking of Surface [gamma]c Protein.
To predict MHC I binding ability, epitope
sequences were subjected to the NetCTL 1.2 Server.
Furthermore, there can be significant differences in optimal protocols required by different antibodies (eg, epitope
As neprilysin degrades epitopes
recognized by standard immunoassays for BNP, recovery of the peptide decreases.
prediction and vaccine candidate characterization have been reported first time for Pakistani field isolate of AAV-4 and could eventually be proposed as an important component of immunodiagnostics and subunit vaccine for future studies.
IgE recognizes conformational epitopes
of larger peptides (B cell epitopes
) and proteins while T cell receptors recognize small linear peptides of 8 to 10 amino acids (T cell epitope
An amino acid stretch must be of a minimum length for being considered as an epitope
that we are aiming to design.