epitope


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epitope:

see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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epitope

[′ep·ə‚tōp]
(immunology)
The portion of the antigen molecule that determines its capacity to combine with the specific combining site of its corresponding antibody in an antigen-antibody interaction.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
The title of her presentation was "Vaccination with DerG LEAPS peptide conjugates incorporating distinct PG (aggrecan) epitopes protects by different immune mechanisms in the PG G1 domain induced mouse model of rheumatoid arthritis."
Diagnostic performance and T-cell epitopes may be different in cattle compared to humans; it is therefore necessary to identify and verify these promising T-cell epitopes in individuals.
Combining the results of four programs, six antigenic epitope peptides (amino acid positions 34-45, 63-67, 103-108, 224-230, 308-316, and 365-377) were predicted (Table 3, Figures 1 and 2).
The sequence corresponding to the B-cell epitope of VP1 from FMDV O1/Campos/Bra/58 (140158) comprises the amino acid residues AVPNVRGDLQVLAQKVART.
The linear B-cell epitopes in the primary amino acid sequence of the coat protein was performed using BCPREDS server with default parameters (http://ailab.cs.iastate.edu/ bcpreds/) which implements a support vector machine (SVM) and the subsequence kernel method (El-Manzalawy et al., 2008a).
Furthermore, there can be significant differences in optimal protocols required by different antibodies (eg, epitope retrieval methods).
As neprilysin degrades epitopes recognized by standard immunoassays for BNP, recovery of the peptide decreases.
Epitope prediction and vaccine candidate characterization have been reported first time for Pakistani field isolate of AAV-4 and could eventually be proposed as an important component of immunodiagnostics and subunit vaccine for future studies.
IgE recognizes conformational epitopes of larger peptides (B cell epitopes) and proteins while T cell receptors recognize small linear peptides of 8 to 10 amino acids (T cell epitope).
An amino acid stretch must be of a minimum length for being considered as an epitope that we are aiming to design.