epitope


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epitope:

see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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epitope

[′ep·ə‚tōp]
(immunology)
The portion of the antigen molecule that determines its capacity to combine with the specific combining site of its corresponding antibody in an antigen-antibody interaction.
References in periodicals archive ?
Synthetic peptides mimicking specific epitopes of infectious viral proteins have been proved to be an alternative to viral antigens in disease diagnosis (Noh et al, 2014).
The computer-generated binding sequences were then made into synthetic epitopes for testing purposes.
Since most of the Asian countries are developing, having nearly similar climatic, hygienic conditions and the mode of viral infection, it was hypothized that promiscuous epitope prediction of A(H1N1)pdm09 virus of Asian origin against Asian HLA can provide more sophisticated results.
Hence, C40 may be used for further investigation as an engineered immunogenic version of its gp41 epitope.
The scientists knew that if they could match a peak highlighted by mass spectrometry to the peptide that produced the greatest T cell reaction, they had found the most heavily favored epitope.
Conserved MHC class I antigen-restricted epitopes present in HA and NP proteins of pandemic (H1N1) 2009 virus * Epitope Identified in selected MHC antigen position Sequence virus isolates HA HLA-A * 0201 344-353 GLFGAIAGFI A/New Caledonia/20/1999 (H1N1) A/Solomon Islands/3/2006 (H1N1) A/Macau/229/2008 (H1N1) A/Managua/254.
5) In contrast to the maturation of the anti-Sm response, patients do not develop antibodies binding the same second Ro epitope.
Hybrids of the Ii-Key linked chemically to an antigenic epitope are potent vaccines in mouse models of human diseases.
The linear IgE-binding epitopes of the Ara h2 allergen have been mapped using overlapping peptides and serum IgE from a population of patients known to be sensitized to peanuts.
Since the ELI vaccine that was used generates random epitope fragments, codon optimization may produce more robust CTL responses.