epitope


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epitope:

see immunityimmunity,
ability of an organism to resist disease by identifying and destroying foreign substances or organisms. Although all animals have some immune capabilities, little is known about nonmammalian immunity.
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epitope

[′ep·ə‚tōp]
(immunology)
The portion of the antigen molecule that determines its capacity to combine with the specific combining site of its corresponding antibody in an antigen-antibody interaction.
References in periodicals archive ?
8226; Quantitative and qualitative - Epitope description includes Positional Weight Matrix of amino acid residues in the peptide epitope motif.
For epitope mapping, we used the peptide library of 18-mer overlapping peptides that covered the entire cTnI sequence.
The epitope is recognized by an antibody called 2F5, which can neutralize several strains of the virus.
A secondary objective of the study was to assess the immunogenicity of the vaccine as measured by the magnitude and epitope breadth of the patients' cellular immune responses.
Complexity of the single linear neutralization epitope of the mouse arterivirus lactate dehydrogenase-elevating virus.
These results demonstrate that protein structure plays an important role in the stability of this allergen to resist digestion and provide a link between food allergen structure, stability to digestion, and the immunodominant IgE-binding epitopes within a population of food-allergic individuals.
A useful approach may involve the use of an expression library, whereby the genome of a pathogen is fragmented and the pieces of DNA captured to create a pathogen library that represents most of the T cell epitopes that exist for that pathogen.
Ninety-one percent of patients treated with EP-2101, who were tested for immune response, had a measurable response to at least one of the epitopes included in the vaccine with 64% responding to at least three of the epitopes.
125]-labeled) that recognizes an epitope different from those recognized by the other four is used as a tracer.
PADRE(R), the Company's proprietary universal HTL epitope, is also included in the vaccine as an immunostimulant.
Epimmune is focused on the development of pharmaceutical products using multiple epitopes to specifically activate the body's immune system.
However, the fact that MAbs recognize only a single epitope means that they have limited usefulness against pathogens that exhibit antigenic variation.