In order to verify the reliability of our experimental method, we compared the equilibrium solubility
, refractive index, and density data with the reported binary system (NaCl + [H.sub.2]O) at different temperatures, and the results are shown in Table 2.
Supersaturated solutions are highly concentrated solutions of drug where the apparent solubility (kinetic solubility) is above the thermodynamic equilibrium solubility
achieved by dissolving the stable crystalline drug.
Determination of Equilibrium Solubility
. Equilibrium solubility
of each of the tested compounds was determined by placing an excess amount of the compound in stoppered glass volumetric flask containing 10 ml of the investigated buffer solution.
Long time exposure was used to determine the equilibrium solubility
. For the wet experiments water was added to the capsules.
Biobor JF is an effective microbiocide because of its equilibrium solubility
in both fuel and water under conditions of fuel storage.
Takacs-Novak, "Study of equilibrium solubility
measurement by saturation shake-flask method using hydrochlorothiazide as model compound," Journal of Pharmaceutical and Biomedical Analysis, vol.
(4) To assess the ability of compounds to dissolve in the gastrointestinal (GI) tract, compounds have to be profiled for equilibrium solubility
via a long incubation time in non-DMSO media or solubility assessment in more physiological simulated buffers to better predict the in vivo performance of a drug after oral administration.
The equilibrium solubility
determines the minimum circulation rate of the solvent through the absorber, determines the maximum allowable concentration of the acid gases in the regenerated solution to meet the product gas specification, and provides boundary conditions for solving partial differential equations describing mass transfer coupled with chemical reactions.
* TIP 0606-10 "Equilibrium Solubility
of Chlorine in Water at 1 atm (14.7 psi)" has been withdrawn by the Pulp Bleaching Committee.
Due to the very different surface areas and internal porosity of samples, equilibrium solubility
of RP in 2% citric acid was reached at different times for different samples, but was generally attained within 24 h.