Before the advent of triptans, ergot derivatives, including ergotamine
tartrate, ergonovine, and dihydroergotamine, were utilized as the treatment of first choice for moderate to severe migraine when simple analgesics did not satisfactorily relieve migraine headache or when they produced significant side effects.
Sprague-Dawley rats were chosen to conduct this experiment (n = 20/group) and ergotamine
was the reference drug.
tartrate and caffeine tablets (marketed by West-Ward Pharmaceutical Corporation and Mikart), Cafergot tablets (marketed by Sandoz), and Ergo-mar sublingual tablets (marketed by Rosedale Therapeutics).
Sumatriptan is reported to have superiority over ergotamine
, in that by itself it does not produce nausea, nor does it cause grogginess, drowsiness, or hangover.
Abortive agents were attempted in 2002, including rizatriptan (Maxalt[R]), which was not effective, and ergotamine
and caffeine suppositories (Cafergot[R]).
Again, timely ergotamine
will usually keep the elephants at bay.
Under the microscope, however, valve tissue from these patients looked virtually identical to valve tissue damaged 6y ergotamine
poisoning or a rare cancer in which high concentrations of serotonin are thought to injure heart valves.
Coramine, 5-hydroxytryptamine, [alpha]-ergocryptine, ergonovine maleate, ergotamine
tartarate, hordenine hemisulfate, L-tryptophan, lysergol, and N-demethyl-LSD (nor-LSD) were purchased from Sigma.
Of the drugs prescribed specifically for the management of migraine, sumatriptan (575 prescriptions to 103 patients) was the most frequently prescribed, followed by 400 prescriptions for ergotamine
Recommended pharmacologic agents include non-steroidal anti-inflammatory drugs, intranasal butorphanol, ergotamine
and its derivatives, and the triptans.
by blunting pain transmission through the use of nonsteroidal anti-inflammatory drugs (NSAIDS) such as indomethacin or caffeine used adjuvantly with NSAIDs or ergotamine
None of the patients had a history of carcinoid syndrome or ergotamine