Towards understanding the pathology of erythema nodosum leprosum
. Trans R Soc Trop Med Hyg.
International workshop on erythema nodosum leprosum
(ENL)--consensus report; the formation of ENLIST, the ENL international study group.
The overall incidence of papulonodular lesions of skin is leprosy (22.67%), erythema nodosum leprosum
(20%), cutaneous tuberculosis and trichoepithelioma (8% each), Prurigo Nodularis, actinomycosis and epidermoid cyst (6.67% each), syringoma and granuloma Annulare (5.33% each), basal cell carcinoma and Jessner lymphocytic infiltrate (4% each), and metastatic carcinoma (2.67%).
Erythema nodosum leprosum
(ENL) recurrence is a serious complication of leprosy immunology that causes inflammation of the skin, nerves and other organs.
[4.] Verma KK, Pandhi RK: Necrotic erythema nodosum leprosum
; A presenting manifestation of lepromatous leprosy.
There was history of rhinorrhea with nasal crusting and epistaxis, pedal edema and erythema nodosum leprosum
lesions, which he developed thrice during his 3-year course of illness along with constitutional disturbances that resolved spontaneously, healing with postinflammatory hyperpigmentation.
Patients with diabetes, alcoholics and those who had reactional episodes [reversal reactions and erythema nodosum leprosum
(ENL)] were excluded, as these are confounding factors in the diagnosis of neuropathic pain.
(1) They described a young female with multibacillary leprosy (MBL) and erythema nodosum leprosum
Though the initial impression was suggestive of lepromatous leprosy with erythema nodosum leprosum
, after careful history and examination a clinical diagnosis of NF 1 with coexisting borderline tuberculoid (BT) leprosy was made.
With only corticosteroids and clofazimine available to combat erythema nodosum leprosum
(ENL) in some of his patients, he recognized the dramatic efficacy of the controversial drug thalidomide in managing ENL and lobbied the federal FDA (Food and Drug Administration) for approval of its use.
Lepromatous leprosy borderline lepromatous leprosy and mid borderline leprosy are included in the multibacillary types.5 The 2 common types of leprosy reactions type 1 or reversal reaction is mediated by an upgrade in cellular immune response to the bacterium and type 2 is a type III hypersensitivity reaction characterized by erythema nodosum leprosum
.67 Nerve damage may occur early in tuberculoid disease but tends to be more insidious in lepromatous leprosy.