Erythrasma


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Erythrasma

 

a keratomycosis caused by parasitic fungi of the genus Microsporum; according to other data, it is caused by corynebacteria of the genus Corynebacterium. Erythrasma, principally a disease of adult males, produces lesions of only the horny layer of the epidermis in the inguinal and scrotal folds and, less commonly, in the intergluteal fold, in the armpits, and under the breasts. The distinct pinkish brown spots have branlike scaling on the surface.

In treating erythrasma, iodine, nitrofungin, or erythromycin ointment is applied to the affected areas, and salicyl spirit is rubbed on.

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Infections may include: impetigo contagiosa, erythrasma, and secondary skin infections such as infected wounds and infected burns.
In the clinical trial conducted in Japan, the percentage of patients who achieved the primary endpoint of HiSCR* at Week 12 after treatment was 13 of 15 patients.3 In the same trial, adverse drug reactions (ADRs) were observed in 6 of 15 patients at Week 24 of treatment; ADRs observed in two or more patients were nasopharyngitis and cellulitis, and other ADRs including dental caries, erythrasma, folliculitis, lymphocyte count increased, erythema, pruritus, and skin exfoliation were observed in one patient each.(3)
Erythrasma, a form of intertrigo, is a superficial infection of the skin caused by Corynebacterium minutissimum, a gram-positive non-spore-forming bacillus (32, 33).
The Wood's lamp revealed a coral-red fluorescence in the interdigital spaces (figure 2), which led us to a diagnosis of erythrasma.
Acne miliaris 4 Acne vulgaris 4 Actinic keratosis 1 Contact dermatitis 2 Epidermoid cyst 1 Erythrasma 1 Keloid 1 Keratosis pilaris 2 Lentigines 1 Melasma 8 Mycosis 2 Nevus 5 Plantar wart 1 Rosacea 1 Scabies 1 Seborrhoeic dermatitis 7 Squamous cell carcinoma 1 Tinea versicolor 4 Venous ulcer 1 Note: Table made from bar graph.
Erythrasma is a chronic superficial bacterial infection of the skin widely prevalent all over the world.
The most frequent conditions are associated with acne syndrome (scars and residual hyperpigmentations with significant psycho-emotional and social impact), atopic dermatitis, all forms of intertigo (favoured by perspiration and microbial spectrum, erythrasma, hidradenitis suppurativa (healing phase with hypertrophic and hyperpigmented scarring), pigmented lichen planus (frequently met in teenagers/adults with skin type III--IV, with hyperpigmented lesions, symmetric, localized on creases and sun exposed areas).
Bacterial infections affecting atheletes include impetigo, folliculitis, furunculosis, erysipelas, cellulitis, erythrasma, pitted keratolysis, hot tub folliculitis and swimming pool granuloma.9
(1) Superficial infections Molluscum contagiosum Bacterial diseases (impetigo, erythrasma, etc.) Dermatophytosis Candidosis Pityriasis versicolor (2) Superficial parasitoses Scabies Demodicidosis Oxyuriasis (3) Xeroses and erythematosquamous, spongiotic and parakeratotic dermatitides Xerosis--kerosis--ichthyo sis Eczema--contact dermatitis Atopic dermatitis Pityriasis rosea Id reaction Psoriasis Seborrheic dermatitis (4) Tumors Malignant melanoma Melanocytic nevus Dysplastic nevus Seborrheic keratosis
Erythrasma presenting as scrotal dermatitis have also been reported.
However these clinical forms, especially the first two, are not always caused by dermatophytes; dyshidrotic eczema, atopic dermatitis, contact dermatitis, juvenile plantar dermatosis, and erythrasma can cause diagnostic difficulty.