Erythroblast


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Related to Erythroblast: monoblast

erythroblast

[ə′rith·rə‚blast]
(histology)
A nucleated cell occurring in bone marrow as the earliest recognizable cell of the erythrocytic series.

Erythroblast

 

intermediate form of development of a red blood cell, or erythrocyte. In mammals and in man, erythroblasts have nuclei and reproduce themselves, unlike mature erythrocytes, which lack nuclei and are unable to reproduce.

In the lower vertebrates (reptiles, amphibians, and fishes), hematopoiesis takes place in the liver, the kidneys, and partly the blood vessels, where erythroblasts may be found together with mature erythrocytes. During the embryonic development of the higher, or warm-blooded, vertebrates (birds and mammals) and man, erythroblasts are formed in the vessels of the yolk sac and transformed into primary erythrocytes, which soon die. In man, they concentrate after birth in the bone marrow, where they develop from hemocytoblasts; it is only in pathological cases that erythroblasts are found in peripheral blood. The number of erythroblasts and their rate of reproduction increase in anemia. After the erythrocyte level in the blood is restored to normal, erythroblast activity in the bone marrow declines.

References in periodicals archive ?
Differences in the Pattern of Histone H3 (K4) and (K27) Methylation throughout the -Globin Gene Locus in Baboon Fetal Liver and Adult Bone Marrow Erythroblasts Pre- and Post-Decitabine Treatment
In occasional cases erythroblasts can be smaller, in the size range of lymphoblasts or lymphoma cells.
That same year, medical geneticist George Stamatoyannopoulos and hematologist Thalia Papayannopoulou of the University of Washington in Seattle reported in vitro results indicating fetal hemoglobin production is stimulated in human adults by the destruction of erythroblasts, a type of bone marrow cell that begets red blood cells.
The peripheral blood smear was notable for marked microcytosis, hypochromia, polychromasia, poikilocytosis, and anisocytosis with numerous erythroblasts.
Because of unsatisfactory sensitivity (fetal erythroblasts, Table 2) (21) and specificity (meconium, Tables 1 and 2) (22-24) of the placental signs of fetal hypoxia, usually only placental hypoxic lesions are instead diagnosed.
c) enhanced proliferation and differentiation of erythroblasts
Excessive apoptosis of bone marrow erythroblasts in a patient with autoimmune haemolytic anaemia with reticulocytopenia.
High levels of fetal erythroblasts and fetal extracellular DNA in the peripheral blood of a pregnant woman with idiopathic polyhydramnios: case report.
The most common finding is normocellular bone marrow with a decrease in erythroblasts (38), (39).
early hematopoietic cells to terminally differentiated enucleating erythroblasts, which suggests distinct functions for these 2 isoforms in hematopoiesis.
Since committed erythroblasts need much more iron than any other cell, they should maintain high TfR1 expression despite high intracellular iron levels.