Erythroblast


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Related to Erythroblast: monoblast

erythroblast

[ə′rith·rə‚blast]
(histology)
A nucleated cell occurring in bone marrow as the earliest recognizable cell of the erythrocytic series.

Erythroblast

 

intermediate form of development of a red blood cell, or erythrocyte. In mammals and in man, erythroblasts have nuclei and reproduce themselves, unlike mature erythrocytes, which lack nuclei and are unable to reproduce.

In the lower vertebrates (reptiles, amphibians, and fishes), hematopoiesis takes place in the liver, the kidneys, and partly the blood vessels, where erythroblasts may be found together with mature erythrocytes. During the embryonic development of the higher, or warm-blooded, vertebrates (birds and mammals) and man, erythroblasts are formed in the vessels of the yolk sac and transformed into primary erythrocytes, which soon die. In man, they concentrate after birth in the bone marrow, where they develop from hemocytoblasts; it is only in pathological cases that erythroblasts are found in peripheral blood. The number of erythroblasts and their rate of reproduction increase in anemia. After the erythrocyte level in the blood is restored to normal, erythroblast activity in the bone marrow declines.

References in periodicals archive ?
Figure 3 shows the morphological characteristics of erythrocytes, erythroblasts, lymphocytes, neutrophils, monocytes, eosinophils, special granulocytic cells (SGC) or PAS-positive granular leukocytes (PAS-GL) and thrombocytes in the blood of O.
C, The lesional cells are focally positive for pancytokeratin (not shown), and they are diffusely immunoreactive for erythroblast transformation-specific transcription factor (ERG) (D), with a low Ki-67 proliferation index (<5%) and (not shown) retained nuclear integrase interactor 1 (INI1) (hematoxylin-eosin, original magnifications X20 [A] and X200 [B]; original magnification X40 [C and D]).
Congenital dyserythropoietic anemias comprise a group of very rare hereditary disorders characterized by ineffective erythropoiesis and distinct morphological abnormalities of erythroblasts in the bone marrow.
quintana is located in erythrocytes during asymptomatic bacteremia (13) and has been observed in erythroblasts in bone marrow in bacteremic patients (14).
Of fetal hypoxic lesions, mild erythroblastosis of fetal blood (Figure 6, A) is regarded as the only reliable (and, therefore, the best) evidence of chronic, in utero hypoxia; however, fetal erythroblasts can also be released from their stores in response to acute hypoxia.
The chromatin of differentiating erythroblasts is cleaved into large size fragments independent of caspase activated DNase and apoptosis inducing factor.
Meanwhile, erythroblasts (cells which give rise to RBC) in the bone marrow begin to mature until they form mature erythrocytes or red blood cells,' says Thad.
This mediator is erythroferrone, a hormone produced by EPO-stimulated erythroblasts.
sup][30] It is then exported by the ferroportin (FPN) to bind to transferrin in the bloodstream,[sup][31],[32] and taken to the erythroblasts for erythropoiesis.
Edited iPSCs distinguished into erythroblasts with re-modeled expression level [28].
Serum transferrin receptor (sTfR) is another marker which is a truncated form of the transferrin receptor present on erythroblasts in bone marrow and many other cells in the body.
During erythrocyte maturation, erythroblasts lose their nuclei to become reticulocytes, and reticulocytes are transformed into erythrocytes by the elimination of their mitochondria.