Lack of erythropoietin results in a lack of stimulation and proliferation of the erythroid
marrow and subnormal red cell level.
No other important findings were noted except for an evident increase in myeloid series and megakaryocytes (more evident in erythroid
series) on bone marrow aspiration and biopsy.
Blast counts should include all blast forms with the exception of erythroblasts, though in the case of pure erythroid
leukemia these should be counted (9).
While not always statistically significant, certain features were more common in CVD than in the control group (Figure), including (1) abnormal bony trabeculae, (2) megaloblastoid changes in the erythroid
lineage, (3) sea-blue histiocytes (SBHs), and (4) ALIP of the granulocytic lineage.
4] Activation of androgen receptors in erythroid
cells appears to be necessary for testosterone to develop an erythropoietic effect in the bone marrow.
Diamond-Blackfan anemia (DBA) is a rare congenital hypoplastic anemia characterized by severe normochromic-macrocytic anemia, reticulocytopenia, a decrease in the number or absence of bone marrow erythroid
precursor cells, and normal megakaryocytic and granulocytic differentiation (1-4).
Previous research has indicated that the transcription factor nuclear factor erythroid
2-related factor 2 (Nrf2) plays an important role in reducing cellular accumulation of methylmercury (MeHg).
Further, laboratory studies have also shown that zidovudine exhibits cytotoxicity to the myeloid and erythroid
precursors in the bone marrow at drug concentrations close to those associated with the optimal antiviral effect in vitro.
9), (10) Philadelphia chromosome or t(9;22) is characteristic of CML as the cytogenetic marker, which is found in myeloid, erythroid
and megakaryocytic lineages.
A paucity of red cell precursors was seen but the erythroid
lineage, approximately 10% of the bone marrow, was maturing appropriately.
Assembly of the Hb [alpha][beta] dimer depends on the presence of a chaperone protein, the [alpha]-Hb-stabilizing protein (AHSP), which forms a heterodimer with [alpha]-Hb in erythroid
Single-cell PCR performed on the DNA extracted from isolated BM erythroid
and myeloid progenitors in the formalin-fixed, paraffin-embedded BM tissue biopsy specimens, collected 2 days before death and at autopsy, were PARV4/5 negative.