Estradiol


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estradiol

[‚es·trə′dī‚ȯl]
(biochemistry)
C18H24O2 An estrogenic hormone produced by follicle cells of the vertebrate ovary; provokes estrus and proliferation of the human endometrium, and stimulates ICSH (interstitial-cell-stimulating hormone) secretion.

Estradiol

 

C18H24O2, a female sex hormone of the estrogen group with the structural formula

Estradiol occurs as colorless crystals with a melting point of 176°–178°C. Poorly soluble in water, it dissolves better in organic solvents. It is optically active, with a specific rotation of [α]D= +81°.

Estradiol was first isolated in 1935 from the follicular fluid of the ovaries of swine by the American biochemist E. Doisy. Of all the estrogens, it has the highest physiological activity, but it is rapidly inactivated in the body. Longer-acting preparations of estradiol (estradiol dipropionate and estradiol benzoate) are obtained by the esterization of estradiol with various organic acids. Estradiol has important physiological functions (seeESTROGEN).

References in periodicals archive ?
The investigators found also that, in contrast with CIMT, cardiac computed tomography (CT) measures of atherosclerosis did not differ significantly between the estradiol and placebo groups, regardless of age.
In a subgroup analysis of postmenopausal women with heart failure, investigators found a significant positive association with the testosterone to estradiol ratio (HR, 1.65; 95% CI, 1.07-2.54) and inverse associations for estradiol (HR, 0.60; 95% CI, 0.39-0.93) and for dehydroepiandrosterone (HR, 0.59; 95% CI, 0.44-0.78).
At first, we found that female rats had few testosterone [Figure 4]a and male rat also showed low amount of estradiol [Figure 4]b as expected, and there were no difference among stressed animals, unstressed control and those in adaption no matter in testosterone [Figure 4]a or estradiol [Figure 4]b.
There appears to be a paucity of data in humans describing the role of estradiol and/or ER activation relative to the expression of genes targeted by ER signaling which are known to play a role in the myogenic activation of satellite cells.
This cell line was derived from a human choriocarcinoma, and it retained the higher capacity to produce estradiol when an exogenous DHEA was provided [13].
Concentrations of progesterone and estradiol in 25-50 [mu]l of plasma were determined in duplicate without extraction by using commercial RIA kits from DSL Laboratories Inc.
The ex vivo resuscitated group, gives direct information about the cardioprotective effects of the treatment with estradiol outside the body, away from any endocrine, neural and other inflammatory pathways interference.
Also, after removing the treatment, 60 blood samples were obtained for determining estradiol levels; five samples were obtained from each specimen with intervals of five days between samples for causing no harm to the animals by the punctures needed for getting the blood.
stream by converting it into estradiol through aromatase in adipocytes.
Progesterone (Sigma-Aldrich, Brazil) and estradiol benzoate (Sigma-Aldrich) were dissolved in an oil vehicle at concentrations of 0.5 and 0.05 mg/mL, respectively.
On the other hand, treatments with eCG can affect ovarian endocrine function and lead to an obvious increase in estradiol productions (Liu et al., 2007).
Estradiol and BPS each increased cell proliferation, but following exposure to both compounds there were fewer cells than in control cultures.