US-based Jubilant Cadista Pharmaceuticals is recalling a number of Drospirenone and Ethinyl Estradiol
Tablets, USP, 3mg/ 0.02mg, 28x3 Blister Pack/Carton that had been on sale to consumers, it was reported yesterday.
"We wanted to prove whether the segesterone in combination with the low dose of ethinyl estradiol
in this unique vaginal system was adequate at inhibiting ovulation and pregnancy as well as providing good cycle control," Archer said.
is a synthetic estrogen that is widely used to treat menopausal symptoms and menstrual disorders and can be used in combination with progestin for contraception.
sales for drospirenone and ethinyl estradiol
tablets USP, 3 mg/0.02 mg were approximately $161 million for the 12 months ended February 28, 2018, according to IQVLA.
Aromatization of norethindrone to ethinyl estradiol
by human placental microsomes.
Another prospective randomized trial showed marked improvement in FG score after 6 months of using cOCPs (containing 0.03mg ethinyl estradiol
and 3mg drospirenone) from 17.3 +- 5.2 to 8.7 +- 2.5 (p<0.001)17.
All received a daily OC (Ortho-Cyclen; 250 meg norgestimate, 35 meg ethinyl estradiol
Furthermore, cycle control with the combined vaginal contraceptive ring has been shown to be superior to that with a combined OCP containing 30 [micro]g ethinyl estradiol
and 150 [micro]g levonorgestrel (10, 11) or 3 mg drospirenone (12).
Pharmaceutical giant Pfizer has recalled 1 million packages of pills--14 lots of Lo/Ovral-28 tablets and 14 lots of generic Norgestrel and Ethinyl Estradiol
tablets--after uncovering a packaging error that included too many active tablets in some packets and not enough in others.
(The OCs with desogestrel or gestodene and 20 mcg of ethinyl estradiol
implied relative risks of VTE that were 23% and 17% lower, respectively, than the risks for the same progestogens with 30 mcg of ethinyl estradiol
John's wort was tested for its effect on Ortho-Novum 1/35, an OC pill containing ethinyl estradiol
The newer methods reviewed in the document include the monophasic pill that contains 30 mcg of ethinyl estradiol
and 0.15 mg of levonorgestrel for extended cycling (Seasonale), the single rod implant that contains the progestin etonogestrel (Implanon), and the vaginal ring (NuvaRing) that contains 15 mcg of ethinyl estradiol
and 120 mcg of etonogestrel and is inserted in the vagina for 3 weeks and removed for 1 week to induce menstruation.