Treatment with mineral oil was associated with an increase in the median concentration of LDL cholesterol (p < 0.001 compared with the change in the icosapent ethyl group
), an increase in the median C-reactive protein concentration (p < 0.001 compared with baseline and compared with the change in the icosapent ethyl group
), and an increase in the incidence of anemia (p = 0.03 compared with icosapent ethyl).
The presented activity of first compound was the most probably due to occurrence of two alkyl groups, at third and fifth positions of aniline ring, that of second and third compounds was credibly due to the presence of two alkyl groups at 3rd/5th of position of aniline ring and benzyl group, along with benzyl and ethyl group
respectively attached to nitrogen of sulfonamide.