Exhaustion

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Exhaustion

 

a state characterized by a lowered level of the functioning of organs, systems, and the body as a whole because of prolonged excessive activity, continuous exposure to powerful stimuli, and certain diseases. The performance of any function is accompanied by intensified decomposition of adenosine triphosphoric acid (ATP) through the utilization of energy accumulated in its terminal phosphate bonds. When ATP formation chronically lags behind its consumption, a precondition for exhaustion is created. The functional elements of organs and systems wear out as they work. The restoration of worn-out structures (functional, energy-forming, and so forth) is based on the synthesis of nucleic acids and proteins. Exhaustion also results if these substances are not synthesized in adequate quantities. The processes of energy formation and protein synthesis are interrelated. The impairment of either may complicate the action of the other and intensify the exhaustion.

Exhaustion may result from extreme fatigue, or slight fatigue after improper or insufficient nutrition, after prolonged exposure to high or low temperatures, after diseases caused by metabolic disorders, and after severe blood losses and injuries. Treatment consists in removing the main causes.

References in classic literature ?
I was not present at the time, but I understood that the subject of dispute was the amount of nourishment which it was necessary to give to assist Miss Halcombe's convalescence after the exhaustion of the fever.
At meal-times all fell to work upon the dishes peculiar to the Southern States, and consumed with an appetite that threatened speedy exhaustion of the victualing powers of Florida, fricasseed frogs, stuffed monkey, fish chowder, underdone
Maud and I worked from dawn till dark, to the limit of our strength, so that when night came we crawled stiffly to bed and slept the animal-like sleep exhaustion.
She put her hand in her pocket and took out the shilling, but the tears came with the sense of exhaustion and the thought that she was giving away her last means of getting food, which she really required before she could go in search of Arthur.
Clare then lay down on the ground alongside, when he immediately fell into the deep dead slumber of exhaustion, and remained motionless as a log.