At necropsy, external abnormalities were limited to the exophthalmic
and buphthalmic left globe with associated periocular swelling and thin body condition.
"Prolonged treatment of exophthalmic goiter by iodine alone." Arch Int Med, 1930; 45:481-502.
"The effect of iodine in exophthalmic goiter." Arch Int Med, 1924; 34:355-364.
The only serious objection raised to the method is the claim that in a certain number of cases a simple and comparatively harmless form of goiter has apparently been developed into the exophthalmic
, or dangerous, form under or after the iodine.
Whole-body radiographs were performed and showed a soft tissue mass in the right orbital region, resulting in an exophthalmic
"The effect of varying quantities of inorganic iodide (carrier) on the urinary excretion and thyroidal accumulation of radioiodine in exophthalmic
goiter." J Clin Invest, 1950; 29:726-738.
The left globe was moderately exophthalmic
, and the nictitans was erythematous and partially protracted.
"The range of effective iodine dosage in exophthalmic goiter." Arch Int Med, 1930; 45:261-281.
"The metabolism pulse ration in exophthalmic goiter and in leukemia." J H Arch Int Med, 1924; 33:576-580.
Since Graves' disease represents up to 90% of hyperthyroidism, (52) we will limit our discussion to Graves' disease, called by different names in different publications: exophthalmic goiter or goitre, hyperthyroidism, and toxic goiter.
(54) In 1863, Trousseau inadvertently used tincture of iodine successfully in a patient with exophthalmic goiter.
"Results of administering iodine to patients having exophthalmic
goiter." JAMA, 1923;80:1955.