Extravasation

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extravasation

[ik‚strav·ə′sā·shən]
(geology)
The eruption of lava from a vent in the earth.
(medicine)
The pouring out or eruption of a body fluid from its proper channel or vessel into the surrounding tissue.

Extravasation

 

the accumulation of blood that has flowed out of the blood vessels into the body cavities or surrounding tissues.

Extravasation may occur when the walls of the vessels are destroyed by a mechanical injury or a pathological process (for example, tumor). It may also occur through an uninjured wall, when the permeability of the wall is increased (for example, under the influence of certain chemical substances). The discharged blood may either permeate the tissues affected by the extravasation or form a circumscribed accumulation, called a hematoma. The significance of extravasation is determined by dimensions, rapidity of development, and site of formation. When the process is minor it is resorbed without treatment. If encapsulated or suppurative, it often requires special treatment. Because extravasation may lead to the destruction of tissue, it is especially dangerous in the brain (insult).

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In both interstitial and necrotizing pancreatitis fluid commonly extravasates from the pancreas and collects in the space surrounding it.
Taking into account our previous observations suggesting that MPO potentiate neutrophils to extravasate into site of inflammation in various other tissues, such as livers [27], we assume that in this case the higher number of neutrophils in the MPO deficient mice is not associated with the higher extent of LPS-induced neutrophil influx into the lungs.
With an average diameter of approximately 100 nm, sphingosomes readily extravasate through these pores and accumulate within the tumor and slowly release the encapsulated drug.
3] If Buck's fascia is disrupted, blood will extravasate into the subcutaneous plane of the scrotum, perineum or pubic areas, resulting in significant swelling.
Sphingosomal drugs like Marqibo(R) readily extravasate through the pores of leaky tumor vessels created during angiogenesis and readily accumulate within the tumor.
Sphingosomal drugs like Marqibo(TM) readily extravasate through the pores of leaky tumor vessels created during angiogenesis and readily accumulate within the tumor.
An external magnet was positioned over the tumor to guide the MTC-DOX into the proper location and to extravasate the material into the tumor parenchyma.