# factor

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Related to factor VIII activity: Factor VIII deficiency

## factor,

in arithmetic, any number that divides a given number evenly, i.e., without any remainder. The factors of 12 are 1, 2, 3, 4, 6, and 12. Similarly in algebra, any one of the algebraic expressions multiplied by another to form a product is a factor of that product, e.g., a+b and ab are factors of a2b 2, since (a+b)(ab)=a2b2. In general, if r is a rootroot,
in mathematics, number or quantity r for which an equation f(r)=0 holds true, where f is some function. If f is a polynomial, r is called a root of f; for example, r=3 and r
of a polynomialpolynomial,
mathematical expression which is a finite sum, each term being a constant times a product of one or more variables raised to powers. With only one variable the general form of a polynomial is a0xn+a1x
equation f(x)=0, then (xr) is a factor of the polynomial f(x).

## factor

[′fak·tər]
(mathematics)
For an integer n, any integer which gives n when multiplied by another integer.
For a polynomial p, any polynomial which gives p when multiplied by another polynomial.
For a graph G, a spanning subgraph of G with at least one edge.
(statistics)
A quantity or a variable being studied in an experiment as a possible cause of variation.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.

## factor

1. Maths
a. one of two or more integers or polynomials whose product is a given integer or polynomial
b. an integer or polynomial that can be exactly divided into another integer or polynomial
2. Med any of several substances that participate in the clotting of blood
3. Law, Commerce a person who acts on another's behalf, esp one who transacts business for another
4. former name for a gene
5. Commercial law a person to whom goods are consigned for sale and who is paid a factorage
6. (in Scotland) the manager of an estate
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005

## factor

A quantity which is multiplied by another quantity.

## factor

A number that divides evenly into another number. For example, 3 and 4 are factors of 12. See factorial and IFP.
Copyright © 1981-2019 by The Computer Language Company Inc. All Rights reserved. THIS DEFINITION IS FOR PERSONAL USE ONLY. All other reproduction is strictly prohibited without permission from the publisher.
References in periodicals archive ?
For the 4e13 vg/kg cohort, mean Factor VIII activity levels over two years support reductions in bleed rates and also show a flattening rate of decline in the one-stage (OS) and chromogenic substrate (CS) assays expressed as an international unit per deciliter (lU/dL).
* VWD is broadly subclassified into quantitative (types 1 and 3) or qualitative (types 2 and PT-VWD) subtypes by use of tests to evaluate protein amount, activity, factor VIII activity, and multimeric distribution.
Coagulation and chromogenic assays of factor VIII activity: general aspects, standardization, and recommendations.
In this assay system, however, high factor VIII activity, lupus anticoagulant, or factor deficiencies (such as induced by warfarin) can produce an abnormally low APCR ratio in addition to Factor V Leiden.
After treatment, 4 of the 6 patients demonstrated increased levels of factor VIII activity, the researchers reported, and "[t]here was a general correlation between these increases and clinical improvement, such as decreased frequency of spontaneous-bleeding episodes or decreased use of...factor VIII [replacement]." The clinical responses noted in these study subjects were encouraging, the authors said, because of evidence that even when factor VIII levels are less than 1.0% of normal, they may be sufficient to protect against bleeding.
As of May 28, 2019, eight patients in the 20-patient cohort of the Phase 3 GENEr8-1 study achieved Factor VIII levels of 40 international units per deciliter, or IU/dL, or more, at 23 to 26 weeks, meeting the pre-specified criteria for Factor VIII activity levels.
Based on draft guidance from the FDA for hemophilia gene therapy products published in 2018, we have the opportunity to pursue a potential accelerated approval path forward based on Factor VIII activity results from a subset of Phase 3 subjects.
M2 PHARMA-May 24, 2018-Bioverativ Factor VIII Therapy Demonstrates Half-life of 37 hours with High Factor VIII Activity Following Single Low Dose
If FDA accepts the firm's IND, the company will evaluate SHP654 in a global multi-center trial, which will include the assessment of the treatment to enhance factor VIII activity levels and affect hemophilic bleeding.

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