In SURUSS, which enrolled 47,000 women, the integrated test had a 93% detection rate with a 5% false-positive rate
. At a four-site demonstration project, the integrated test had a 91% detection rate.
Its performance appears to be of the same order as older estimates for AFP, with an almost identical univariate detection rate as AFP when it was initially studied (20% for AFP vs 21% for fetal DNA, both at a 5% false-positive rate
The false-positive rates
among these tests range from about 22% with the PEDS and the Battelle to 45% using the Denver-II, Dr.
On the other hand, those who believe their risk is low tend to select the test with the lowest possible false-positive rate
, which they perceive to be the most efficient, he said.
The detection rate was plotted against the false-positive rate
Allowing the patients to have second serum samples taken reduced the overall MSAFP false-positive rate
for neural tube defects from 3.2% to 1.8%, she said.
Thus, MS/MS screening reduces the false-positive rate
because it identifies disorders on the basis of improved quantitation via the stable isotope dilution technique together with the pattern of metabolite abnormalities as opposed to screening for a single metabolite increase that is often transient.
As for the prediction of the specific diagnosis of polyps, the sensitivity of endometrial vascularity via power Doppler was 89%, but the positive predictive value was only 46% and the false-positive rate
Because of its low false-positive rates
, this method is an efficient way to screen for large numbers of disorders in individuals while minimizing the cost of follow up because of low false-positive rates
In one large multicenter study in England, nuchal translucency screening alone in the first trimester had a sensitivity of 70% for detection of Down syndrome with a false-positive rate
of 4.6% (Lancet 352:343-46, 1998).
(b) "Their FPDC technique performed worse than capillary blood technique, with a much greater false-positive rate
." The third paragraph of the abstract of the paper by Schonfeld et al.
An integrated approach using both nuchal thickness and four-chamber view results proved 50% sensitive for heart defects with a false-positive rate