Chugani, "Absence of arcuate fasciculus
in children with global developmental delay of unknown etiology: a diffusion tensor imaging study," Journal of Pediatrics, vol.
Peak MNI coordinates White matter regions X Y Z L angular gyrus -35 -61 34 R cerebellar 23 -70 -33 L precentral white matter -7 -22 55 L lateral occipital -32 -83 14 L superior longitudinal fasciculus
-33 -62 26 L supramarginal gyrus -40 -47 33 L postcentral white matter -11 -34 58 White matter regions Cluster size Peak p (voxels) value L angular gyrus 50 0.002 R cerebellar 57 0.002 L precentral white matter 65 0.002 L lateral occipital 107 0.001 L superior longitudinal fasciculus
114 0.002 L supramarginal gyrus 129 0.005 L postcentral white matter 145 0.002
From an anatomical point of view the inferior longitudinal fasciculus
and the inferior fronto-occipital fasciculus
have been classically considered the two major associative pathways responsible for the epileptic propagation in OLE to temporal and frontal areas, probably because of their close relationship with the optic radiation within the sagittal stratum of Sachs (Figure 5).
Of particular interest are data on the arcuate fasciculus
, this pathway is critically involved with human language.
 found that the white matter tracts connecting frontotemporoparietal regions were directly related to impaired word comprehension involving control processes, where structural integrity and strength of functional connectivity of uncinate fasciculus
(UF) predicted semantic control abilities among the participants.
Analysis of the subcomponents and cortical terminations of the perisylvian superior longitudinal fasciculus
: a fiber dissection and DTI tractography study.
Finally, a third cross-sectional study of binge drinking adolescents and concomitant binge drinking and substance using adolescents found that binge drinking adolescents, again, had lower FA than control subjects in eight different regions, including the superior corona radiata (SCR), inferior longitudinal fasciculus
, superior longitudinal fasciculus
(SLF), inferior fronto-occipital fasciculus
(IFOF), and cerebellar peduncle.
However, we detected bilateral conduction block in the fasciculus
gracilis in somatosensory evoked potentials (SEP).
Caption: Figure 5: The vehicle-treated NMO rats demonstrated visible demyelination (shown by MBP immunofluorescence, green) in the optic nerve (a-e) and spinal cord (f-j, anterior horn; k-o, posterior fasciculus
Moreover, a significant decline of emotion recognition skills (particularly affecting the identification of negative emotions) has been found related to microstructural changes (measured through fractional anisotropy) in right inferior longitudinal fasciculus
and inferior frontooccipital fasciculus
in nondemented ALS patients .
Fractional anisotropy ratio (FA), which is a marker of the white matter integrity, was shown to be reduced in the frontal, temporal, and parietal lobes; cerebellum; corpus callosum; internal and external capsules; superior longitudinal fasciculus
; corona radiata; commisural limbic; brainstem; and cortical projection fibers in young binge drinkers.