"Twenty percent of red blood cells with fetal hemoglobin
-- what we saw with this method -- would be close to a level sufficient to reverse symptoms of sickle cell disease."
Baldwin et al., "Fetal hemoglobin
in sickle cell anemia: genetic studies of the Arab-Indian haplotype," Blood Cells, Molecules and Diseases, vol.
The influence of fetal hemoglobin
on the frequency of vasoocclusive crisis in sickle cell anemia patients.
Verma et al., "Homozygous delta-beta thalassemia in a child: a rare cause of elevated fetal hemoglobin
," Iranian Journal of Pediatric Hematology and Oncology, vol.
Masala, "Disorders of the synthesis of human fetal hemoglobin
," IUBMB Life, vol.
shortened erythrocyte survival), increased fetal hemoglobin
, carbamylated hemoglobin, iron replacement therapy, and transfusion requirements may interfere with Hb [A.sub.1c] measurement (1-3).
In HBSS disease fetal hemoglobin
(HbF) is a major modulator of polymerization in that the higher the HbF levels, the more benign the clinical and hematologic features of sickle cell anemia .
The presence of fetal hemoglobin
(HbF) seems to protect babies and younger children from problems of ACS; as hemoglobin F declined with age, risk for ACS increases.
Hb electrophoresis in all these cases revealed high Hb F (fetal hemoglobin
).The cases of sickle cell disease presented with aches and pains in different parts and joints of the body.
(3) Iron chelation therapy, splenectomy, transfusion therapy, and modulation of fetal hemoglobin
(HbF) production are several available options for managing patients with [beta]-TI.
Apart from gene therapy, fetal hemoglobin
reactivation by chemical agents appears promising enough to develop into effective interventions to cure human [beta]-hemoglobinopathies.