The extra fetal hemoglobin
in their blood, which has a very strong affinity for oxygen, does the work of the defective adult hemoglobin.
The value of fetal hemoglobin
level in the management of Nigerian sickle cell anemia patients.
Experts have known for some time that inhibiting or reversing gamma-to-beta switching of hemoglobin subunits can raise levels of fetal hemoglobin
in adults and significantly ameliorate the debilitating symptoms of beta-thalassemia or sickle cell disease.
Table 1: Hb: hemoglobin, HPLC: high performance liquid chromatography, HbS: sickle cell hemoglobin, HbF: fetal hemoglobin
, HbA and HbA2: adult hemoglobin, and PTH: parathyroid hormone.
Reactivation of fetal hemoglobin
in patients with beta-thalassemia.
The potential of reactivating fetal hemoglobin
via manipulating the gene transcription of [beta]- or [gamma]-globin has been gained much attention recently.
The team obtained similar results in human adult red blood cells, forcing the cells to produce fetal hemoglobin
On the chromatographic heterogeneity of human fetal hemoglobin
Finally, data from a study we performed on a different group of mountain climbers who lived at high altitude (ranging from 3100 to 5600 m above sea level, Nevado Copa mountain in Peru) for 17 days, strongly support the hypothesis that, like in other instances of stress erythropoiesis such as in thalassemia or sickle cell syndromes, also in hypoxia more RBCs containing fetal hemoglobin
, named fetal RBCs, are generated (in our study 5.
Accurate prediction of fetal hemoglobin
by Doppler ultrasonography.
Neonates are assumed to be able to counteract natural infection with malaria because of the predominance of fetal hemoglobin
, which is not suitable for complete erythrocyte schizogony of P.
Most US laboratories perform a qualitative screen for excess FMH using the fetal rosette test, followed, if positive, by a Kleihauer-Betke-type stain of the maternal blood smear to count the percentage of RBCs with fetal hemoglobin