fibrin

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fibrin:

see blood clottingblood clotting,
process by which the blood coagulates to form solid masses, or clots. In minor injuries, small oval bodies called platelets, or thrombocytes, tend to collect and form plugs in blood vessel openings.
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The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Fibrin

 

a protein of high molecular weight formed by the action of the enzyme thrombin on blood plasma fibrogen; it is composed of smooth or transversely striated fibers, agglomerations of which form the basis of the thrombus occurring when blood coagulates.

Fibrin is formed in three stages. In the first stage, two peptides A (molecular weight approximately 2,000) and two peptides B (molecular weight approximately 2,500) split off from the fibrinogen molecule by the action of thrombin, forming the fibrin monomer, which is constructed of two identical subunits joined by disulfide bonds. Each of the subunits consists of three dissimilar polypeptide chains, which are designated α, β, and γ.

In the second stage, the fibrin monomer spontaneously converts to a clot, which is called a fibrin aggregate, or nonstabilized fibrin. The aggregation of the fibrin monomer (the self-assembly of fibrin fibers) includes the transition of the molecule from the globular state to the fibrillary state. Hydrogen and electrostatic bonds and forces of hydrophobic interaction, which may be weakened in concentrated solutions of urea and other denaturing agents, participate in the formation of the fibrin aggregate. This process leads to the reconstitution of the fibrin monomer. The formation of the fibrin aggregate is accelerated by substances that carry a positive charge, such as calcium ions and protamine sulfate, and is inhibited by negatively charged compounds, such as heparin.

In the third stage the fibrin aggregate undergoes changes caused by the enzymatic action of the fibrin-stabilizing factor XIIIa, or fibrinase. Through the action of this factor, stable covalent bonds are formed between the γ- and α-polypeptide chains of fibrin-aggregate molecules, as a result of which the fibrin aggregate is stabilized as a fibrin polymer that is insoluble in concentrated solutions of urea. In cases of congenital or acquired insufficiency of factor XIIIa in the body and in certain diseases, the fibrin aggregate is not stabilized as a fibrin polymer, resulting in hemorrhagic diatheses.

Fibrin is obtained by rinsing and drying a blood clot. It is used to prepare sterile sponges and films for stopping hemorrhages from small vessels during various surgical operations.

REFERENCE

Belitser, V. A., and T. V. Varetskaia. “Fibrinogen i fibrin: stroenie molekul, samosborka volokon.” Uspekhi sovremennoi biologii, 1975, vol. 80, issue 1(4).

I. P. BASKOVA

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.

fibrin

[′fī·brən]
(biochemistry)
The fibrous, insoluble protein that forms the structure of a blood clot; formed by the action of thrombin.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.

fibrin

a white insoluble elastic protein formed from fibrinogen when blood clots: forms a network that traps red cells and platelets
Collins Discovery Encyclopedia, 1st edition © HarperCollins Publishers 2005
References in periodicals archive ?
(51.) Tirindelli MC, Flammia GP, Bove P, et al: Fibrin glue therapy for severe hemorrhagic cystitis after allogeneic hematopoietic stem cell transplantation.
Matsuyama, "Endoscopic tissue shielding method with polyglycolic acid sheets and fibrin glue to prevent delayed perforation after duodenal endoscopic submucosal dissection," Digestive Endoscopy, vol.
Rachlin, "CT-guided percutaneous fibrin glue therapy of cerebrospinal fluid leaks in the spine after surgery," American Journal of Roentgenology, vol.
Group one received treatment with fibrin glue seeded with ASCs, group two received ASCs injected with PBS, and group three received fibrin glue alone.
Vertical split conjunctival autograft using fibrin glue is an effective surgical technique for the treatment of primary double-headed pterygia achieving zero recurrence rate and good cosmetic appearance up to one year in our study sample.
The dural and tegmenal defects were repaired using a galeal graft, fat removed from the abdomen and autogenous fibrin glue. The removed bone window was then replaced.
In the literature, there are also experimental studies in which sclerosing agents such as fibrin glue, Poliethylene oxide dimethacrylate, albumin gluteraldehyde, cornybacterium parvum, 5- Fluorourasil, Microporous Polysaccharide spherules, Myhtilus edilus protein were used.
Given the patient's refusal of surgical treatment, we injected fibrin glue from the external hole; however, discharge recurred 3 months late.
Different therapies are being used to treat anal fistula world wide ranging from fistulotomy to fibrin glue plug and radiofrequency ablation12.
The use of fibrin glue at the deep cuff and laparoscopic surgical sites may facilitate earlier catheter use.
analyzed the effect of the use of an autologous falciform ligament patch with fibrin glue for both stapler and hand-sewn closure of the pancreatic remnant and reported a rate of clinically relevant POPF Grades B and C in 18% of their patients which did not differ significantly from the control group [30].
A second operation was performed by removing the Hartshill rectangle with posterior reconstruction of the dural sac with fascia lata, fibrin glue, and tight water closure of the dura mater.