fibronectin


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fibronectin

[′fī·brə′nek·tən]
(biochemistry)
A type of large glycoprotein that is found on the surface of cells and mediates cellular adhesion, control of cell shape, and cell migration.
References in periodicals archive ?
In the present study, we confirmed that an E/N-cadherin switch occurred in CCA cells following TGF-[beta]1-induced EMT, whereby exposure of TFK-1 cells to TGF-[beta]1 resulted in the loss of the epithelial marker E-cadherin, and increased N-cadherin and Fibronectin, resulting in transformation of the myofibroblastic morphology (Sato et al., 2010), as well as stress fiber reorganization by F-actin.
There were two parts to the investigational screening protocol: collection of a fetal fibronectin swab at three gestational time points and transvaginal ultrasound to measure cervical length at time of the second and third fibronectin measurement.
Plasma and cellular fibronectin: distinct and independent functions during tissue repair.
The preterm prediction study: fetal fibronectin testing and spontaneous preterm birth.
Induction of Fibronectin, Collagen IV, and Laminin mRNA and Protein Expression under High Glucose Conditions.
The goal of this study is to determine the affinity of [alpha]5[beta]1 integrins on NIH/3T3 fibroblasts for fibronectin adsorbed onto functionalized electrospun PCL scaffolds.
In particular, accumulation of collagen type III and V, and to a lesser degree type I collagen and fibronectin in the reticular layer has been associated with asthma [64,65].
Several studies have now recognized that increased glucose level in aqueous induces increase in fibronectin synthesis and its accumulation in the trabecular meshwork with depletion of normal trabecular meshwork cells.9,10 Is fibronectin synthesis in the trabecular meshwork a missing link for increase prevalence of glaucoma in DM has to be proven in further studies.
Matrix metalloproteinases (MMPs) not only degrade collagen, fibronectin and laminins but also activate heparin binding-epidermal growth factor (HB-EGF) which is also a ligand of EGFR and belongs to EGF family of cytokines.
The study "Fibronectin rescues estrogen receptor a from lysosomal degradation in breast cancer cells," was led by RocEaA[degrees]o Sampayo.
The Fibronectin type-III 2-domain, Fibronectin type-III 3-domain, Insulin in-binding-region, protein kinase-like domain, juxtamembrane region and partial Fibronectin type-III 1-domain are absent (Figure 2) (5).
Despite the fact that integrins ([alpha] - and [beta] chains) are well known to exist in all metazoan, its presumptive ligand, fibronectin (FN, as fibronectin-like protein, FN-LP) evolutionary originate as novel ECM components in Urochordate species C.