Fibrosarcoma

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fibrosarcoma

[¦fī·brō·sär′kō·mə]
(medicine)
A sarcoma composed of spindle cells that produce collagenous fibrils.

Fibrosarcoma

 

an immature malignant tumor of connective tissue; a malignant variant of fibroma, fibromyoma (leiomyoma), or fibroadenoma that can occur in any part of the body. It is characterized by invasive and destructive growth but sometimes has distinct contours. In cross section it looks like fish flesh. A fibrosarcoma has a marked capacity to metastasize, chiefly through blood vessels. It can often be distinguished from a fibroma only by histological examination and is treated surgically.

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The prognostic significance of fibrosarcomatous transformation in dermatofibrosarcoma protuberans.
In this case, the mesenchymal elements composed of fibrosarcomatous malignant cells characterized by undifferentiated anaplastic spindle cells resembled mature fibroblast in a storiform pattern and the immunohistochemical analysis.
Fibrosarcomatous changes in DFSP usually occur in primary de novo neoplasm, as fascicular, rather than storiform, architecture, a greater cellularity with increased mitotic activity and necrosis.
Vergani et al., "Adaptive immunity in fibrosarcomatous dermatofibrosarcoma protuberans and response to imatinib treatment," Journal of Investigative Dermatology, vol.
Occasionally, Bednar tumour may undergo fibrosarcomatous transformation with rare examples of pulmonary metastasis.
Devadoss, "Pediatric gliosarcoma with fibrosarcomatous differentiation: report of a rare case," Indian Journal of Pathology and Microbiology, vol.
The fibrosarcomatous subtype is associated with a relatively favorable prognosis in both species (30).
Approximately 10% of DFSP are a more aggressive subtype with fibrosarcomatous progression FS- DFSP.