cephalosporin(redirected from first-generation cephalosporin)
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cephalosporin(sĕf'əlōspôr`ĭn), any of a group of more than 20 antibioticsantibiotic,
any of a variety of substances, usually obtained from microorganisms, that inhibit the growth of or destroy certain other microorganisms. Types of Antibiotics
..... Click the link for more information. derived from species of fungi of the genus Cephalosporium and closely related chemically to penicillinpenicillin,
any of a group of chemically similar substances obtained from molds of the genus Penicillium that were the first antibiotic agents to be used successfully in the treatment of bacterial infections in humans.
..... Click the link for more information. . Cephalosporins, e.g., cefaclor (Ceclor), act against both gram-positive and gram-negative bacteria (see Gram's stainGram's stain,
laboratory staining technique that distinguishes between two groups of bacteria by the identification of differences in the structure of their cell walls. The Gram stain, named after its developer, Danish bacteriologist Christian Gram, has become an important tool
..... Click the link for more information. ) by inhibiting bacterial cell wall synthesis. They are widely used to treat gonorrhea, meningitis, and staphylococcal and streptococcal infections in patients who cannot use penicillin. Overuse of cephalosporins has led to increased bacterial resistance to the drugs (see drug resistancedrug resistance,
condition in which infecting bacteria can resist the destructive effects of drugs such as antibiotics and sulfa drugs. Drug resistance has become a serious public health problem, since many disease-causing bacteria are no longer susceptible to previously
..... Click the link for more information. .)
Any of a group of antibiotics produced by strains of the imperfect fungus Cephalosporium.