floxuridine


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floxuridine

[‚fläks′yu̇r·ə‚dēn]
(pharmacology)
C9H11FN2O5 Crystals that melt at 150-151°C; used as an antiviral drug and as an inhibitor of deoxyribonucleic acid synthesis. Abbreviated FUDR.
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Friedman et al., "A randomized trial of continuous intravenous versus hepatic intraarterial floxuridine in patients with colorectal cancer metastatic to the liver: the Northern California Oncology Group trial," Journal of Clinical Oncology, vol.
The authors reported the quantitative reverse-transcription polymerase chain reaction (qRT-PCR) analysis of tumour specimens from 94 patients who had advanced CRC and were treated with hepatic arterial infusion of floxuridine and dexamethasone in combination with systemic treatment with irinotecan after resection of liver metastases.
* Where the physical setting of administration of the drug or the experience and training of the physician is critical--for example, because of severe toxic reactions, all patients receiving floxuridine should be hospitalized for first course therapy; and
For example, cholestasis may be caused by a change in the chemical and physical properties of the hepatocytic membranes, as with estrogens, or by an associated allergic or autoimmune attachment to the hepatocyte or the microscopic bile ducts, as with phenothiazines and related antipsychotic agents, or by a sclerosing cholangitis of the intermediate and large bile ducts, as with intra-arterial infusion of floxuridine.(6)