Fluorescein

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fluorescein

[‚flu̇′re·sē·ən]
(organic chemistry)
C20H12O5 A yellowish to red powder, melts and decomposes at 290°C, insoluble in water, benzene, and chloroform, soluble in glacial acetic acid, boiling alcohol, ether, dilute acids, and dilute alkali; used in medicine, in oceanography as a marker in sea water, and in textiles to dye silk and wool.

Fluorescein

 

a dye; yellow crystals. Fluorescein is poorly soluble in water; it dissolves better in alcohols and dilute alkalies. Decomposition occurs at the melting point, 314°–316°C. In aqueous solutions, fluorescein exists as a 1:1 mixture of the benzoid (I) and quinoid forms and has a strong yellow-green fluorescence (hence the name). Its structural form is

Fluorescein belongs to a group of triarylmethane (xanthene) dyes. It colors silk and wool yellow but is not used in the textile industry because of poor colorfastness. It is used to trace the course of underground waters. Its disodium salt (uranine) is a component of fluorescing mixtures, and its isothiocyanate derivatives are used as biological stains for identifying antigens and antibodies. Some halogen-substituted fluoresceins, such as eosins, also have practical value.

Fluorescein is produced by the condensation of phthalic anhydride with resorcinol.

References in periodicals archive ?
Fluorescein strips intended for diagnostic purposes are regarded as medicinal products because they are in vivo diagnostic agents.
Recently, there has been considerable debate about the use of CE marked fluorescein strips since Fluorets, the only medically licensed (pharmacy only medicinal product) fluorescein strips, were withdrawn from the global market.
Crucially, the Optical Confederation insurance bodies--the AOP, ABDO and FODO have all agreed to continue to cover and defend members, who use CE-marked fluorescein strips in the normal way.
ADVICE WHICH supports the use of fluorescein strips in routine community practice has been published by the Optical Confederation.

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