fluorouracil


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fluorouracil:

see metabolitemetabolite,
organic compound that is a starting material in, an intermediate in, or an end product of metabolism. Starting materials are substances, usually small and of simple structure, absorbed by the organism as food. These include the vitamins and essential amino acids.
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fluorouracil

[¦flu̇r·ō′yu̇r·ə‚sil]
(pharmacology)
C4H3FN2O2 Crystals that decompose at 282-283°C; used as an antineoplastic drug and as an inhibitor of deoxyribonucleic acid synthesis. Also known as 2,4-dioxo-5-fluoropyrimidine; 5-FU.
References in periodicals archive ?
Long-term survival after epirubicin, cisplatin and fluorouracil for gastric cancer: results of a randomized trial.
These results "indicate that treating a patient with a single course of fluorouracil would reduce the subsequent number of spot treatments and benefit care of patients with multiple AKs for longer than 2 years," concluded Dr.
Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer.
Neither cryosurgery nor fluorouracil was used in 35% of U.
2] Fluorouracil 5% USP cream may cause fetal harm and should not be used in women who are, or may become, pregnant during therapy.
Phase III trial of infusional fluororuracil, leucovorin, oxaliplatin and irinotecan (FOLFOXIRI) compared with infusional fluorouracil, leucovorin and irinotecan (FOLFIRI) as first-line treatment for metastatic colorectal cancer.
Capecitabine patients had significantly lower rates of neutropenia, stomatitis, nausea, vomiting, alopecia, and diarrhea than fluorouracil plus leucovorin patients, but severe hand-foot syndrome occurred significantly more often in capecitabine patients.
Women in the treatment group got a brief course of chemotherapy -- cyclophosphamide, methotrexate, fluorouracil and leucovorin -- 36 hours after surgery and again a week later.
Certain statements in this release may be considered forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995, including statements regarding the Company's fluorouracil cream.
Leucovorin and fluorouracil with or without oxaliplatin as first-line treatment in advanced colorectal cancer.
Patients were randomized to receive an infusion of Taxotere 75 mg/m2 plus cisplatin 75 mg/m2 on day one, and a five-day continuous infusion of fluorouracil 750 mg/m2 daily or intravenous cisplatin 100 mg/m2 on day one followed by five-day continuous infusion of fluorouracil 1000 mg/m2 per day.
The addition of bevacizumab to irinotecan, fluorouracil, and leucovorin (IFL) increased the overall median survival of patients who were receiving primary treatment for metastatic colorectal cancer to 20.