fluorouracil


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fluorouracil:

see metabolitemetabolite,
organic compound that is a starting material in, an intermediate in, or an end product of metabolism. Starting materials are substances, usually small and of simple structure, absorbed by the organism as food. These include the vitamins and essential amino acids.
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fluorouracil

[¦flu̇r·ō′yu̇r·ə‚sil]
(pharmacology)
C4H3FN2O2 Crystals that decompose at 282-283°C; used as an antineoplastic drug and as an inhibitor of deoxyribonucleic acid synthesis. Also known as 2,4-dioxo-5-fluoropyrimidine; 5-FU.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
During the study period, more participants treated with fluorouracil had complete clearance of AKs on the face and ears, compared with the control group (P less than .001).
5- Fluorouracil: A pharmacological paradigm in the use of cytotoxics.
Phase III trial in metastatic gastroesophageal adenocarcinoma with fluorouracil, leucovorin plus either oxaliplatin or cisplatin: A study of the Arbeitsgemeinschaft Internistische Onkologie.
Neither cryosurgery nor fluorouracil was used in 35% of U.S.
Nondermatologists used cryosurgery alone on 32% of their AK patients, 0.5% fluorouracil on no patients, 5.0% fluoro-uracil on 3%, and a combination of fluorouracil and cryosurgery on no patients.
Although topical fluorouracil can help reduce actinic keratoses and cure some superficial basal cell and squamous cell carcinomas, it has not been studied as a strategy to prevent the development of lesions that might require surgery, wrote Martin A.
US scientists led by Dr Dana Sachs, of the University of Michigan Medical School, have found that besides reducing potentially cancerous skin patches, Fluorouracil ointment, also known as Efudex, can mend the damage seen on sun- exposed faces.
Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial.
In the first study, researchers in the National Surgical Adjuvant Breast and Bowel Project (NSABP) studied 679 node-negative patients, finding that women given chemotherapy -- a combination of methotrexate and fluorouracil - had an 80 percent disease-free survival rate four years later, compared with 71 percent of controls.