Keywords: Ion-selective electrode, potentiometric titration, drug analysis, fluoxetine hydrochloride
The researchers disclosed past financial relationships with Forest Laboratories Inc., which markets Lexapro (escitalopram oxalate) and Celexa (citalopram hydrobromide), and with Eli Lilly 8C Co., which markets Prozac (fluoxetine hydrochloride
* Antidepressants, such as the selective serotonin reuptake inhibitors (SSRIs) including sertraline hydrochloride (Zoloft) and fluoxetine hydrochloride
(Prozac), citalopram (Celexa), escitalopram (Lexapro) and paroxetine (Paxil); selective noradrenaline reuptake inhibitors (SNRIs), including venlafaxine (Effexor) and duloxetine (Cymbalta); and tricyclic antidepressants, including amitriptyline (Elavil), nortriptyline (Pamelor), desipramine (Norpramin), and imipramine (Tofranil); and atypical antidepressants such as bupropion (Wellbutrin) and trazodone (Desyrl)
When Lilly was still marketing the drug, the "physician information" section of its Web site for Sarafem said that "fluoxetine was initially developed and marketed as an antidepressant (Prozac, fluoxetine hydrochloride
)," while patients were told, in their section of the Web site, that "Sarafem contains fluoxetine hydrochloride
, the same active ingredient found in Prozac."
, as it is generically known, was discovered in 1972 by scientists working for US-based Eli Lilly and Company.
In a study presented at the November 2003 annual meeting of the Society of Environmental Toxicology and Chemistry, Baylor University's Bryan Brooks determined that fluoxetine hydrochloride
(the active ingredient in the antidepressant Prozac) excreted into the sewer system is accumulating in the tissues of bluegill caught in nearby Denton Creek.