follicle-stimulating hormone


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Related to follicle-stimulating hormone: luteinizing hormone, prolactin

follicle-stimulating hormone

(FSH): see gonadotropic hormonegonadotropic hormone
or gonadotropin,
any one of three glycoprotein (see protein) hormones released by either the anterior pituitary gland or the placenta (the organ in which maternal and fetal blood exchange nutrients and waste products) that have various effects upon
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.
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The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Follicle-Stimulating Hormone

 

(FSH), a gonado-trophic hormone in man and other vertebrates produced by the anterior pituitary.

Chemically, the hormone is a glycoprotein; its primary structure has not been established. The molecular weight of FSH in sheep is 67,000; the molecular weight for swine is 29,000. The molecule consists of two subunits, alpha and beta. The alpha sub-unit is similar to the alpha subunits of luteinizing and thyrotropic hormones, whereas the beta subunit differs from the beta subunits of these hormones. The biological properties of FSH are determined solely by the beta subunit (in lizards, the beta subunit is as active as the native hormone). In females, FSH stimulates the development of follicles up to ovulation and promotes the growth of ovarian interstitial tissue; these effects lead to an increase in the secretion of female sex hormones, or estrogens. In males, FSH promotes the growth of the seminiferous tubules and stimulates spermatogenesis and the secretion of male sex hormones, or androgens. FSH acts jointly with the luteinizing hormone.

The synthesis and excretion of FSH are regulated both by the FSH releasing factor, which is elaborated by the hypothalamus, and by the levels of androgen and estrogen in the blood; as the concentrations of androgen and estrogen increase, the secretion of FSH decreases.

REFERENCES

Pankov, Iu. A. “Struktura i svoistva gipofizarnykh gormonov,” part 2: “Belkovye gormony gipofiza.” Problemy endokrinologii, 1974, vol. 20, no. 3.
Pierce, J G. “Properties of Pituitary Thyroid-stimulating Hormone in Comparison With Those of the Gonadotropins.” Biochemical Society Transactions, 1974, vol. 2, no. 5.

V. M. SAMSONOVA

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.

follicle-stimulating hormone

[¦fäl·ə·kəl ¦stim·yə‚lād·iŋ ′hȯr‚mōn]
(biochemistry)
A protein hormone released by the anterior pituitary of vertebrates which stimulates growth and secretion of the Graafian follicle and also promotes spermatogenesis. Abbreviated FSH.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
References in periodicals archive ?
Follicle-stimulating hormone receptor (FSHR): a promising tool in oncology?
Taking a basal follicle-stimulating hormone history is essential before initiating in vitro fertilization.
Layman, "The molecular basis of impaired follicle-stimulating hormone action: Evidence from human mutations and mouse models," Reproductive Sciences, vol.
The role of thyroid hormone as a biological amplifier of the actions of follicle-stimulating hormone in the functional differentiation of cultured porcine granulosa cells.
Inhibition of follicle-stimulating hormone-induced preovulatory follicles in rats treated with a nonsteroidal negative allosteric modulator of follicle-stimulating hormone receptor.
The cell grafts not only secreted adrenocorticotropic hormone, prolactin, and follicle-stimulating hormone, but they also triggered appropriate hormonal responses in the kidneys.
Moderately elevated levels of basal follicle-stimulating hormone in young patients predict low ovarian response, but should not be used to disqualify patients from attempting in vitro fertilization.
Patient's luteinizing hormone and follicle-stimulating hormone levels were within normal limits.
Aside from the most common symptoms, your GP can offer a blood test to measure your levels of follicle-stimulating hormone (FSH, which regulates reproductive processes) and oestradiol (the oestrogen produced by the ovaries).
Potential role of follicle-stimulating hormone (FSH) and transforming growth factor (TGFp1) in the regulation of ovarian angiogenesis.
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Both these drugs prompt the pituitary to secrete follicle-stimulating hormone, which enhances the growth of small follicles and thus can trigger ovulation.

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