Hyperkeratosis

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hyperkeratosis

[¦hī·pər·ker·ə′tō·səs]
(medicine)
Hypertrophy of the cornea.
Hypertrophy of the horny layer of the skin.
McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copyright © 2003 by The McGraw-Hill Companies, Inc.
The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Hyperkeratosis

 

excessive development of the corneous layer of the skin in humans. Hyperkeratosis may be caused by external factors (such as prolonged pressure, friction, or the effects of lubricating oils) or internal factors (endocrine dysfunctions, hypovitaminosis A, occupational intoxication). Hyperkeratosis is manifested by the formation of horny plates, nodes of various sizes, protuberances, and spurs; the skin becomes dry and perspiration decreases. Hyperkeratosis may be accompanied by the formation of painful cracks (on the palms and soles). It may be limited (calluses, warts, keratomas) or diffuse, spread over large areas or the entire skin surface (ichthyosis). Treatment consists in soda or soap baths, vitamin therapy, and medications that dissolve the horny substance.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
The punch biopsy should demonstrate follicular hyperkeratosis overlying multiple fragmented hair shafts that are surrounded by a perifollicular lymphohistiocytic infiltrate with extravasated red blood cells.
By this way, it is possible to assess the density of hair follicles per surface area and to observe the presence of follicular hyperkeratosis (kerosis), as well as comedones, trichostasis spinulosa, intrafollicular bacteria, and mites [7-11].
This may fight acne by inhibiting sebaceous hyperplasia, follicular hyperkeratosis, and inflammation.
Follicular hyperkeratosis may be observed, particularly on the posterior aspect of the upper arms or the lateral portion of the thighs.
The microscopic changes included atrophy or moderate acanthosis of the epidermis, with formation of rete ridges, marked superficial and follicular hyperkeratosis. There was severe atrophy of the hair follicles, with swelling, vacuolization and lysis of keratinocytes, resting sometimes only the sebaceous glands.
A patient may have night blindness, an eye disease called xerophthalmia that can lead to corneal ulcers and blindness, or a dry, scaly skin condition known as follicular hyperkeratosis.

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