follicle-stimulating hormone

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Related to follitropin: follitropin alpha, follitropin beta

follicle-stimulating hormone

(FSH): see gonadotropic hormonegonadotropic hormone
or gonadotropin,
any one of three glycoprotein (see protein) hormones released by either the anterior pituitary gland or the placenta (the organ in which maternal and fetal blood exchange nutrients and waste products) that have various effects upon
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.

Follicle-Stimulating Hormone

 

(FSH), a gonado-trophic hormone in man and other vertebrates produced by the anterior pituitary.

Chemically, the hormone is a glycoprotein; its primary structure has not been established. The molecular weight of FSH in sheep is 67,000; the molecular weight for swine is 29,000. The molecule consists of two subunits, alpha and beta. The alpha sub-unit is similar to the alpha subunits of luteinizing and thyrotropic hormones, whereas the beta subunit differs from the beta subunits of these hormones. The biological properties of FSH are determined solely by the beta subunit (in lizards, the beta subunit is as active as the native hormone). In females, FSH stimulates the development of follicles up to ovulation and promotes the growth of ovarian interstitial tissue; these effects lead to an increase in the secretion of female sex hormones, or estrogens. In males, FSH promotes the growth of the seminiferous tubules and stimulates spermatogenesis and the secretion of male sex hormones, or androgens. FSH acts jointly with the luteinizing hormone.

The synthesis and excretion of FSH are regulated both by the FSH releasing factor, which is elaborated by the hypothalamus, and by the levels of androgen and estrogen in the blood; as the concentrations of androgen and estrogen increase, the secretion of FSH decreases.

REFERENCES

Pankov, Iu. A. “Struktura i svoistva gipofizarnykh gormonov,” part 2: “Belkovye gormony gipofiza.” Problemy endokrinologii, 1974, vol. 20, no. 3.
Pierce, J G. “Properties of Pituitary Thyroid-stimulating Hormone in Comparison With Those of the Gonadotropins.” Biochemical Society Transactions, 1974, vol. 2, no. 5.

V. M. SAMSONOVA

follicle-stimulating hormone

[¦fäl·ə·kəl ¦stim·yə‚lād·iŋ ′hȯr‚mōn]
(biochemistry)
A protein hormone released by the anterior pituitary of vertebrates which stimulates growth and secretion of the Graafian follicle and also promotes spermatogenesis. Abbreviated FSH.
References in periodicals archive ?
Association of human follitropin (FSH) receptor with splicing variant of human lutropin/choriogonadotropin receptor negatively controls the expression of human FSH receptor.
Irrespective of this, It automatically ends with the entry into force of the exclusive contract for follitropin alfa, Atc g03ga05, As a result of a formal award procedure in accordance with the regulations of part 4 of the gwb with one or more contractual partners.
Europium and samarium as labels in time-resolved immunofluorometric assay of follitropin.
Tenders Are Invited for Conclusion of a non-exclusive rebate agreement pursuant to 130a (8) sgb v on the active substance follitropin alfa, Atc code: G03ga05, For the period from 1.
Circulating antibodies to monoclonal immunoglobulins used in a follitropin assay may cause incorrect fertility diagnosis.
This observation was successfully exploited in the development of a separation immunoassay for the simultaneous measurement of follitropin and lutropin (LH) in serum (20).
hCG free [alpha] is immunologically indistinguishable from lutropin, follitropin, and thyrotropin free [alpha].
The early follicular phase is characterized by relatively high plasma concentrations of follitropin (FSH) (4) and by low concentrations of lutropin (LH), estradiol, progesterone, and inhibin.
Additionally, serial blood samples were obtained from 20 different women throughout the course of their menstrual cycles and clinically evaluated for LH, follitropin (FSH), and estradiol on the Opus and other commercial systems.