follicle-stimulating hormone

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Related to follitropin: follitropin alpha, follitropin beta

follicle-stimulating hormone

(FSH): see gonadotropic hormonegonadotropic hormone
or gonadotropin,
any one of three glycoprotein (see protein) hormones released by either the anterior pituitary gland or the placenta (the organ in which maternal and fetal blood exchange nutrients and waste products) that have various effects upon
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.

Follicle-Stimulating Hormone

 

(FSH), a gonado-trophic hormone in man and other vertebrates produced by the anterior pituitary.

Chemically, the hormone is a glycoprotein; its primary structure has not been established. The molecular weight of FSH in sheep is 67,000; the molecular weight for swine is 29,000. The molecule consists of two subunits, alpha and beta. The alpha sub-unit is similar to the alpha subunits of luteinizing and thyrotropic hormones, whereas the beta subunit differs from the beta subunits of these hormones. The biological properties of FSH are determined solely by the beta subunit (in lizards, the beta subunit is as active as the native hormone). In females, FSH stimulates the development of follicles up to ovulation and promotes the growth of ovarian interstitial tissue; these effects lead to an increase in the secretion of female sex hormones, or estrogens. In males, FSH promotes the growth of the seminiferous tubules and stimulates spermatogenesis and the secretion of male sex hormones, or androgens. FSH acts jointly with the luteinizing hormone.

The synthesis and excretion of FSH are regulated both by the FSH releasing factor, which is elaborated by the hypothalamus, and by the levels of androgen and estrogen in the blood; as the concentrations of androgen and estrogen increase, the secretion of FSH decreases.

REFERENCES

Pankov, Iu. A. “Struktura i svoistva gipofizarnykh gormonov,” part 2: “Belkovye gormony gipofiza.” Problemy endokrinologii, 1974, vol. 20, no. 3.
Pierce, J G. “Properties of Pituitary Thyroid-stimulating Hormone in Comparison With Those of the Gonadotropins.” Biochemical Society Transactions, 1974, vol. 2, no. 5.

V. M. SAMSONOVA

follicle-stimulating hormone

[¦fäl·ə·kəl ¦stim·yə‚lād·iŋ ′hȯr‚mōn]
(biochemistry)
A protein hormone released by the anterior pituitary of vertebrates which stimulates growth and secretion of the Graafian follicle and also promotes spermatogenesis. Abbreviated FSH.
References in periodicals archive ?
In China, Recombinant Follitropin Beta is used to treat anovulation (including polycystic ovary disease, PCOD) that cannot be cured by clomiphene citrate.
The Follistim AQ Cartridge is designed to be used only with the Follistim Pen (TM), an innovative pen device that facilitates accurate delivery of individualized doses of pre-mixed follitropin beta injection, a highly effective and widely used prescription fertility medication made from state of the art recombinant DNA technology.
The data shows that individualised treatment with REKOVELLE, as compared to treatment with conventional rFSH (follitropin alfa), had similar results for the co-primary endpoints of ongoing pregnancy rates and ongoing implantation rates.
Ferring Pharmaceuticals, a multinational pharmaceutical company, has received recommended approval from the European Medicines Agency's Committee for Medicinal Products for Human Use (CHMP) for its Rekovelle (follitropin delta) for controlled ovarian stimulation in women undergoing assisted reproductive technologies, it was reported yesterday.
Molecular, structural, and cellular biology of follitropin and follitropin receptor.
HCG[alpha] is essentially identical to that of lutropin (LH), follitropin (FSH), and thyrotropin (TSH), whereas hCG[beta] is unique to hCG and confers its biological and immunological specificity (1).
Ovarian stimulation was conducted with recombinant follicle-stimulating hormone (follitropin beta, Puregon; Organon), starting at a daily dose of 50-100 IU on the third day of the cycle.