Twenty-four hours after forebrain
ischemia, the hippocampus, cortex and striatum were obtained and homogenized.
[alpha]-Synuclein immunostaining indicated LBD within the brainstem, limbic structures of mesial temporal lobe, and basal forebrain
(not shown), and the presence of only sparse Lewy bodies in the temporal neocortex.
Interaction of basal forebrain
cholinergic neurons with the glucocorticoid system in stress regulation and cognitive impairment.
The crucial step in the above experiment was differentiation of hESC-derived neural progenitor cells towards a forebrain
progenitor fate by pretreatment with SHH and FGF8.
This study showed that the forebrain
glutamatergic neuron-specific SNAP-25 cKO lead to a typical SZ-like phenotype.
To examine the effects of GBE on cholinergic neurons, the number of ChAT-positive cells in the basal forebrain
was estimated by using immunohistochemistry.
Acute electrical stimulation targeting the medial forebrain
bundle (MFB) and associated pathways have been investigated in preclinical models of psychiatric disorders [30-33]; however, the consequences of chronic and continuous MFB stimulation have not been previously studied.
High-voltage-activated calcium currents in basal forebrain
neurons during aging.
Dr Karen K Hsiao Ashe, Dr Jada Lewis and Dr Michael Hutton have developed the rTg4510 mice that exhibit many salient characteristics of hereditary human dementia in an age-dependent manner covering cognitive impairment, motor deficits, the presence of neurofibrillary tangles and neuronal loss in the forebrain
Given the abundant expression of [Ca.sub.V]2.1 channels in the cerebrum, it was hypothesized that functional [GABA.sub.A] receptor subunit expression may be altered in the forebrain
of tgrol mice.
where S1a to S6a represent the forebrain
areas in sections 1 to 6, respectively.
The optical fractionator method was used to estimate the total number of p75NTR positive neurons in one out of 20 forebrain
sections by an operator blinded to the animal's diagnostic classification.