The same degree of foreign body reaction
was observed in both groups in the first month.
Histopathological examination did not indicate any difference in terms of inflammation, foreign body reaction
, or granulation tissue formation between the groups, and it was observed that the perineural sheath and myelin structure were preserved in all nerves without any axonal degeneration.
Foreign body reaction
was not detected in any of the control group samples and there were no significant difference between study groups and control groups (Fisher Exact test, P-value=0.224).
In our study, no chronic inflammation, mucosal atrophy, necrosis, foreign body reaction
or muscular atrophy was identified in any of the vocal cords two months after PRP injection.
The biomembrane formed at the defect site is due to body's foreign body reaction
to the antibiotic-impregnated cement spacer.
However, this causal factor is rarer in children, being the more common bone loss caused by foreign body reaction
, in which the presence of foreign materials lead to rupture of the epithelium and contact with the connective tissue generating local inflammatory reactions.
Apart from mechanisms underlying CD154 contribution, the control of the foreign body reaction
in order to slow or prevent the formation of a fibrotic capsule remains a major challenge in the field of biomaterial research.
Peck, "Foreign body reaction
to a bioabsorbable interference screw after anterior cruciate ligament reconstruction," BMJ Case Reports, 2009.
Head, "Foreign body reaction
to inhalation of lentil soup: giant cell pneumonia," Journal of Clinical Pathology, vol.
Improvements remain to be made in the balance between durability, foreign body reaction
, amount of material, chronic pain, and time to recovery .
Anderson found that foreign body reaction
can impact the biocompatibility of biomaterials and influence short- and long-term tissue responses .
These include immune response, foreign body reaction
with the isolation of the implant with a vascular connective tissue, possible infection and impact on the lifespan of the implant [21,23].