If there was any visual indication of poor adhesion, the formulation
was given a 0.
The addition of the new formulation
to our product lineup of opioid analgesics will provide another treatment option for patients suffering from cancer pain and further enhance our contribution to healthcare in Japan.
The new technology developed by InnoCore allows the development of injectable sustained release biologic formulations
with conserved bioactivity of these sensitive molecules.
The 118 FDC formulations
gave rise to 3307 brand-named products made by 476 pharmaceutical manufacturers, including a dozen multinational companies.
Three replicate determinations were made for each capsule formulation
Sample: FDA-approved doxycycline tablets (100 mg), capsules (100 mg), and liquid suspension (10 mg/mF), and compounded doxycycline formulations
from three pharmacies (tablets [25, 100, and 150 mg; one product/source], chews [100 mg; one product/source], and liquid suspensions or solution [6 mg/mF, two sources and 50 mg/mF, one source]).
Where, n is the number of time points, Rt is the dissolution value of the reference formulation
at time t, and Tt is the dissolution value of the test formulation
at time t.
Typically, a finished formulation
contains a variety of active compounds.
Ongoing and future trials utilising the oral formulation
of the product are unaffected by this regulatory action.
In addition, the presence of ethanol in the formulation
encourages the formation of lamellar-shaped vesicles which have been reported to improve the solubility and entrapment of many drugs including minoxidil and testosterone [6, 7].
"This new web-based tool complements our popular formulation
box, by allowing greater convenience with mobile access and the immediate availability of new formulations
," said Feifei Lin, North America market leader for PharmaSolutions, Dow Corning.