Immunohistochemically, both lesions are positive for MUC6 protein (a pyloric gland mucin marker), are negative for MUC5AC (a foveolar
mucin marker), and demonstrate a very low proliferative activity index by Ki-67/MIB-1.
Divergent expression of MUC5AC, MUC6, MUC2, CD10, and CDX-2 in dysplasia and intramucosal adenocarcinomas with intestinal and foveolar
morphology: is this evidence of distinct gastric and intestinal pathways to carcinogenesis in Barrett esophagus ?
glands were elongated, irregular, and focally dilated.
However, typical features of portal hypertensive polyps reportedly include foveolar
hyperplasia of the epithelium as well as proliferating, ectatic capillaries in the lamina propria; this indicates their portal hypertensive nature and distinguishes them from inflammatory polyps (Figure 4) [3, 7, 8,11,14].
However, sometimes they can show focal staining with MUC5A (a foveolar
marker, positive in gastric foveolar-type adenomas, Figure 2(b)) and MUC1 (a pancreatobiliary marker, positive in biliary-type adenomas).
cells are severely dilated with regular dilation patterns.
Eyes with CME showed large cystic spaces in the foveolar
and parafoveal region.
Mostly, the tumor occupied the submucosa, infiltrated into the deeper layers, and extended to broad foci in the mucosa expanding the lamina propria without involving the foveolar
glands [Figure 2]c and [Figure 2]d.
Mucosa was characterized by the reduced height of surface epithelium, flattened epitheliocytes in both surface and foveolar
epithelium with nuclei displacement in central parts of the cells, and preservation of clear cell boundaries.
Images were taken outside the foveolar
Suterwala, "Gastric foveolar
metaplasia and gastric heterotopia in the duodenum: No evidence of an etiologic role for Helicobacter pylori," Human Pathology, vol.