fragile site


Also found in: Medical.

fragile site

[′fraj·əl ¦sīt]
(genetics)
The chromosomal position of a deoxyribonucleic acid sequence predisposed to spontaneous or induced breakage; sometimes contains short repetitive sequences.
References in periodicals archive ?
Despite all of this significance, the fragile site has also gone through various periods of decay and neglect in its history.
2 fragile site and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers.
Correlated fragile site expression allows the identification of candidate fragile genes involved in immunity and associated with carcinogenesis.
Almost all cases of FXS are caused by the expansion of a CGG repeat in the 5' untranslated region of the fragile X mental retardation gene (FMR-1) (OMIM #309550) at the FRAXA fragile site Xq27.
Instead of a trip to Disneyland, the top prize is a $20,000 award for the winning class to continue or expand its project--whether that's protecting a local habitat, kick-starting a renewable energy effort or cleaning up environmentally fragile site.
However, if it is common to find only one copy deleted then the deletions may be passengers and it may well be a fragile site.
X-linked mental retardation, macro-orchidism, and the Xq27 fragile site.
ABSTRACT : An investigation to determine frequency and distribution of folate sensitive chromosomal fragile sites was carried out in a Pakistani breed of Lohi sheep to uncover fragile site phenomena.
The selection of Petra as one of the New Seven World Wonders, says Aysar Akrawi, PNT's executive director, "has served as a wake up call for the need to manage this fragile site.
Mexicans are beaming about the recent designation of the Chichen Itza Mayan temple city as one of the new Seven Wonders of the World in July, but the reaction is mixed on the impact that an expected surge in visitors will have on the fragile site.
They immediately notified a local archaeologist and a dig was quickly organised on the fragile site.