Despite all of this significance, the fragile site
has also gone through various periods of decay and neglect in its history.
The FHIT gene, spanning the chromosome 3p14.2 fragile site
and renal carcinoma-associated t(3;8) breakpoint, is abnormal in digestive tract cancers.
Correlated fragile site
expression allows the identification of candidate fragile genes involved in immunity and associated with carcinogenesis.
The FHIT gene spans the most common fragile site
in the human genome, FRA3B (3p14.2) .
Almost all cases of FXS are caused by the expansion of a CGG repeat in the 5' untranslated region of the fragile X mental retardation gene (FMR-1) (OMIM #309550) at the FRAXA fragile site
Although the exact mechanism of fragile site
expression still remains unclear, however some external factors have been implicated to be instrumental for their expression.
Instead of a trip to Disneyland, the top prize is a $20,000 award for the winning class to continue or expand its project--whether that's protecting a local habitat, kick-starting a renewable energy effort or cleaning up environmentally fragile site
. The students and their schoolmates will also be treated to a Disney concert in May 2011.
However, if it is common to find only one copy deleted then the deletions may be passengers and it may well be a fragile site
In most cases, a fragile site
is detected at Xq27.3, which harbours the FMR1 gene (4).
ABSTRACT : An investigation to determine frequency and distribution of folate sensitive chromosomal fragile sites
was carried out in a Pakistani breed of Lohi sheep to uncover fragile site
The selection of Petra as one of the New Seven World Wonders, says Aysar Akrawi, PNT's executive director, "has served as a wake up call for the need to manage this fragile site
." She added further that "signing this project is recognition of the need to create the infrastructure that will enhance the quality of the visitor's experience through the introduction of management procedures and improved visitor services.
Mexicans are beaming about the recent designation of the Chichen Itza Mayan temple city as one of the new Seven Wonders of the World in July, but the reaction is mixed on the impact that an expected surge in visitors will have on the fragile site
. The site, in central Yucatan state, includes the seven-story Kukulkan pyramid, the Temple of Chac Mool, the Hall of the Thousand Pillars, and the Playing Field of the Prisoners.