frameshift mutation

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Related to Frame-shift mutation: point mutation, missense mutation

frameshift mutation

[¦frām‚shift myü′tā·shən]
(genetics)
The addition or deletion of nucleotides to anexon in numbers other than three, which shifts the translation reading frame so a new set of codons beyond the point of abnormality in the messenger ribonucleic acid is read. Also known as phase-shift mutation.
References in periodicals archive ?
The latter feature may be indicative of an immune response to the high rate of truncated proteins formed as a result of multiple frame-shift mutations induced by MSI [66] and may underlie their favourable outcome.
Coexpression of substantially different wild-type and mutant peptides, because of nonsense or frame-shift mutations, produced more variable ratios of expression judged by either criterion.
Over the past decades several cases of genetic polymorphisms, described in peer-reviewed papers and listed in the analbuminemia register (2), have been characterized as representing site-specific mutations, splice-site mutations, or frame-shift mutations. The deletion reported by Dolcini et al.
Overall, 95 samples had high-frequency microsatellite instability (HFMI), which refers to frame-shift mutations and base-pair substitutions in short, tandemly repeated nucleotide sequences (N.
Point lesions manifest themselves in 2 ways: substitutions and frame-shift mutations. Depending on whether the correct amino acid is still coded for, substitutions may or may not result in mutation.
Most are frame-shift mutations, which are thought to produce C-terminal truncated forms of ASXL1.
Indeed gross deletion, nonsense mutations, frame-shift mutations, and splicing defects are not reported for this gene.