fumagillin


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fumagillin

[‚fyü·mə′jil·ən]
(microbiology)
C26H34O7 An insoluble, crystalline antibiotic produced by a strain of the fungus Aspergillus fumigatus.
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References in periodicals archive ?
Fumagillin and its analogs have been used topically to treat corneal infections and orally for gastrointestinal microsporidiosis (27), but because of possible side effects, they have not been used to treat microsporidial myositis (27).
Telomerase activity was reduced in MM cell lines in comparison with normal cells by inhibition of MetAP2 (methionine amino-peptidase) with angiostatic agents fumagillin and ovalicin.
Alan Cherrington of Vanderbilt University in Nashville, who has worked on a related drug, fumagillin, said, "Indeed, it would appear that the drug increases the breakdown of fat," though the complete mechanism is not yet known.
The company's second clinical compound, XMT-1107, a novel fumagillin conjugate, which was licensed to Teva Pharmaceuticals in 2010, is currently in Phase 1 studies.
The studies showed that XMT-1107, a novel anti-angiogenic fumagillin analog conjugated to Mersana's proprietary Fleximer(R), demonstrated superior anti-tumor activity in tumor xenograft models in comparison to other anti-angiogenic agents and extended exposure to the conjugated drug, supporting the potential clinical utility of XMT-1107 as an anti-cancer agent.
Potent anti-angiogenic action of AGM-1470: comparison to the fumagillin parent.
Zafgen will present a clinical update on beloranib and Phase 1b study highlights, as well as a poster for fumagillin, a prototype methionine aminopeptidase 2 (MetAP2) inhibitor.
XMT-1107 is a novel anti-angiogenic fumagillin analog that employs Mersana's Fleximer platform.
GENERAL FUMAGILLIN DESCRIPTION, COMPOSITION, INFORMATION ON INGREDIENTS, HAZARDS IDENTIFICATION, HANDLING AND STORAGE, TOXICOLOGICAL & ECOLOGICAL INFORMATION, TRANSPORT INFORMATION
to develop and commercialize XMT-1107, a novel fumagillin analog, for the treatment of all indications, including cancer.