Gamma-Aminobutyric Acid

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The following article is from The Great Soviet Encyclopedia (1979). It might be outdated or ideologically biased.

Gamma-Aminobutyric Acid

 

NH2CH2CH2CH2COOH, an acid formed by the decarboxylation of glutaminic acid under the action of the enzyme decarboxylase. In the body, metabolism of gamma-aminobutyric acid gives succinic acid, which participates in the tricarboxylic acid cycle. Free gamma-aminobutyric acid is found in many plants. In higher mammals gamma-aminobutyric acid is only found in the brain, where its concentration reaches 100 mg percent. Gamma-aminobutyric acid is assumed to exert a retarding action on nerve activity, which is apparently associated with its effect on the permeability of biological membranes.

The Great Soviet Encyclopedia, 3rd Edition (1970-1979). © 2010 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Thus, glutamatergic and GABAergic connectivity within the PFC has received much attention in the context of SZ, particularly concerning cognitive function.
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This postulate is backed up by the studies showing an increased function in glutamatergic neurons and decreased function in GABAergic neurons.
Dysfunction of GABAergic transmission is associated with many neurological disorders including schizophrenia, epilepsy, depression and autism spectrum disorder (Luscher et al., 2011).
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A number of mechanisms have been suggested for central sensitization, among which there is strongest evidence for the dysfunction of GABAergic interneurons and their role in modifying synaptic transmission of pain signaling pathways in response to PNI [11-13].
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In the dentate gyrus, glutamatergic and GABAergic synapses act as the major sources of excitation and inhibition, respectively [2, 27].